Language: English / Subject: Molecular biology | Search Results

1. Analysis of Conformational Continuum and Free-energy Landscapes from Manifold Embedding of Single-particle Cryo-EM Ensembles of Biomolecules

: Seitz, Evan Elliott
: 2022
: Theses
: Molecular biologyBiomoleculesElectron microscopy—Data processingMachine learningRiemannian manifoldsGibbs' free energyPath analysis (Statistics)RibosomesCOVID-19 (Disease)--Data processing

2. Bacterial Genome Engineering with CRISPR RNA-Guided Transposons

: Vo, Phuc Hong
: 2022
: Theses
: Molecular biologyMicrobiologyBacterial geneticsBacterial genomesTherapeuticsEscherichia coli--GeneticsTransposonsDNACRISPR (Genetics)

3. Characterization of pathogenic BicD2 mutations in vitro and in vivo.

: Yi, Julie Young Joo
: 2022
: Theses
: CytologyMolecular biologyNeurosciencesMicrotubulesEukaryotic cellsDyneinMutagenesisKinesin

4. Single-cell Analysis of Alopecia Areata

: Lee, Yoo Jin
: 2022
: Theses
: ImmunologyMolecular biologyAlopecia areata--Animal modelsMiceBaldnessPathologyCytokinesLymphocytesNucleotide sequenceCancer--Treatment

5. A p53-independent role for MDM2-MDMX in cell cycle progression

: Klein, Alyssa Michelle
: 2021
: Theses
: CytologyMolecular biologyBiochemistryCancerMutation

6. Discovery of Novel Ferroptosis Regulators Using Genetic and Lipidomic Analyses

: Bezjian, Carla Tara
: 2021
: Theses
: CytologyMolecular biologyBiochemistryCell deathGenetic regulationPhospholipids

7. Epitranscriptomic Alterations in Alzheimer’s Disease: The Role of MicroRNA Methylation in the Regulation of Tau Proteostasis

: Kim, Yoon Anna
: 2021
: Theses
: NeurosciencesPathologyMolecular biologyAlzheimer's disease--Genetic aspectsMicroRNAMethyltransferasesNervous system--DegenerationPhosphorylationDrosophila--GeneticsRats--GeneticsMice--Genetics

8. Function and Regulation of ALS/FTD-associated RNA Binding Protein FUS

: Tsai, Yueh-Lin
: 2021
: Theses
: BiologyCytologyMolecular biologyRNA-protein interactionsAmyotrophic lateral sclerosisDementia

9. Leveraging the potential of human iPSC-derived cardiomyocytes: From modeling congenital heart disease to treating myocardial infarction

: Liu, Bohao
: 2021
: Theses
: Biomedical engineeringMolecular biologyMedicineMyocardial infarctionCongenital heart diseaseHeart cellsStem cellsHuman beings

10. Mutagenic Repair Outcomes of DNA Double-Strand Breaks

: Al-Zain, Amr M.
: 2021
: Theses
: BiologyMolecular biologyDouble-stranded RNACancer--EtiologyCancer--Genetic aspectsGenomesMutagenesis

11. Neurometabolic alterations after traumatic brain injury: Links to mitochondria-associated ER membranes and Alzheimer’s disease

: Agrawal, Rishi Raj
: 2021
: Theses
: Molecular biologyCytologyNeurosciencesBrain--Wounds and injuriesAlzheimer's disease--EtiologyMitochondrial membranes

12. Non-apoptotic Caspase-8 Signaling Mediates Retinal Angiogenesis

: Johnson, Kendra Vincia
: 2021
: Theses
: NeurosciencesCytologyMolecular biologyRetina--DiseasesRetina--Blood-vesselsNeovascularizationRetinal degeneration--Animal models

13. Phenotypic dissection and therapeutic manipulation of cell differentiation programs in the salivary gland epithelium and human Adenoid Cystic Carcinomas

: Viragova, Sara
: 2021
: Theses
: CytologyMolecular biologySalivary glandsEpithelium--DiseasesAdenoid cystic carcinomaCancer--Radiotherapy

14. Pparg Drives Luminal Differentiation and Luminal Tumor Formation in the Urothelium

: Tate, Tiffany
: 2021
: Theses
: OncologyCytologyMolecular biologyUrinary organsBladder--CancerBasal cell carcinoma

15. Spatially determined olfactory receptor choice is regulated by Nfi-dependent heterochromatin silencing and genomic compartmentalization

: Bashkirova, Elizaveta Vladimirovna
: 2021
: Theses
: Molecular biologyHeterochromatinOlfactory receptorsOlfactory receptor genes

16. Stress and Rab35 modulate Alzheimer’s disease-related protein trafficking

: Zhuravleva, Viktoriya
: 2021
: Theses
: NeurosciencesBiologyMolecular biologyAlzheimer's disease--ResearchStress (Physiology)Glucocorticoids

17. Structure and Function of a Transposon-Encoded CRISPR-Cas System

: Halpin-Healy, Tyler Sheehan
: 2021
: Theses
: BiochemistryBiophysicsMolecular biologyVibrio choleraeRNADNA

18. The role of RNA base modification m⁶A in RNA turnover and genome dynamics in B cell programmed DNA recombination

: Nair, Lekha
: 2021
: Theses
: ImmunologyMolecular biologyRNADNAMethyltransferasesMethylationGene rearrangement

19. Atf5 Links Olfactory Receptor Induced Stress Response to Proper Neuronal Function

: Kahiapo, Jerome Keoki
: 2020
: Theses
: CytologyBiochemistryMolecular biologyOlfactory receptor genesSmellSensory neuronsMammals

20. Evolutionary and Functional Diversity of Regulatory Factors and Sequences that Coordinate Gene Expression

: Park, Jimin
: 2020
: Theses
: Biology--ClassificationMolecular biologyMicrobiologyGenetic regulationGene expressionDNA--Synthesis

21. Generative Models for Synthetic Biology

: Blazejewski, Tomasz
: 2020
: Theses
: BioinformaticsBiology--ClassificationMolecular biologySynthetic biologyMachine learningAmino acid sequence

22. Leveraging DNA Damage Response Pathways to Enhance the Precision of CRISPR-Mediated Genome Editing

: Nambiar, Tarun S.
: 2020
: Theses
: GeneticsMolecular biologyGene editingGenomesDNA

23. Neuronal Topography in a Cortical Circuit for Innate Odor Valence

: Costantini, Daniel
: 2020
: Theses
: NeurosciencesMolecular biologyOlfactory receptorsOdorsMiceNeurons

24. Proximal-distal patterning of the lung: molecular determinants in lung development and evolution

: van Soldt, Benjamin Jonathan
: 2020
: Theses
: Developmental biologyGeneticsMolecular biologyLungsPulmonary alveoliMammals--Development

25. RNA mediated mechanisms of motor neuron death and dysfunction in SMA

: Van Alstyne, Meaghan
: 2020
: Theses
: CytologyMolecular biologySpinal muscular atrophyMotor neuronsRNA

26. The autophagosomal perspective: Tissue-specificity and cell-specificity of the autophagic response to starvation in vivo

: Yang, Young Joo
: 2020
: Theses
: Molecular biologyBioinformaticsVeterinary medicineAutophagic vacuoles

27. The contribution of bone to the physiology of danger

: Berger, Julian Meyer
: 2020
: Theses
: EndocrinologyNeurosciencesMolecular biologyBonesDanger perception--ResearchMiceRatsHuman beings

28. The FYN-TRAF3IP2 gene fusion drives oncogenic NF-κB signaling in peripheral T cell lymphoma

: Kim, Christine Sheila
: 2020
: Theses
: Molecular biologyGeneticsOncologyHTLV (Viruses)CarcinogenesisGene fusion

29. The Role of N6-methyladenosine RNA Methylation in the Regulation of Hematopoietic Stem Cells

: Lee, Heather
: 2020
: Theses
: CytologyMolecular biologyHematopoietic stem cellsDNA--MethylationCell differentiation

30. The role of SMARCAD1 during replication stress

: Joseph, Sarah
: 2020
: Theses
: Molecular biologyGeneticsBreast--Cancer--Genetic aspectsOvaries--Cancer--Genetic aspectsHeterozygosity

31. Understanding the Evolution of Recombination Rate Variation and PRDM9

: Baker, Zachary
: 2020
: Theses
: Biology--ClassificationEvolution (Biology)Molecular biologyMeiosisGenetic recombination

32. Chloride Intracellular Channel (CLIC) proteins function to modulate Rac1 and RhoA downstream of endothelial G-protein coupled receptors signaling

: Mao, De Yu
: 2019
: Theses
: PharmacologyChloride channelsMolecular biologyCytology

33. Control of cellular plasticity during tissue remodeling in C. elegans

: Aghayeva, Ulkar
: 2019
: Theses
: NeurosciencesMolecular biologyCaenorhabditis elegansTissue remodelingNeuroplasticity

34. Elevated cellular cholesterol in Familial Alzheimer’s presenilin 1 mutation is associated with lipid raft localization of β-amyloid precursor protein

: Cho, Yoon Young; Kwon, Oh-Hoon; Park, Myoung Kyu; Kim, Tae-Wan; Chung, Sungkwon
: 2019
: Articles
: Alzheimer's disease--Genetic aspectsPresenilinsCholesterolMolecular biology

35. Elucidating synergistic dependencies in lung adenocarcinoma by proteome-wide signaling-network analysis

: Bansal, Mukesh; He, Jing; Peyton, Michael; Kustagi, Manjunath; Iyer, Archana; Comb, Michael; White, Michael; Minna, John D.; Califano, Andrea
: 2019
: Articles
: AdenocarcinomaMolecular biologyLungs--Cancer--Molecular aspectsProteomics

36. Engineering Responsive Yeast Systems Using Fungal G-Protein-Coupled Receptors

: Brisbois, James Ronald
: 2019
: Theses
: Molecular biologyChemistryCell interactionG proteins--ReceptorsYeast fungi

37. ER stress and lipid droplet-dependent proteostasis in response to lipid stress in yeast and a novel congenital muscular dystrophy

: Garcia, Enrique Jose
: 2019
: Theses
: Molecular biologyCytologyLecithinMuscular dystrophyLipids

38. Function and tissue focus of daf-18/PTEN in maintaining blast cell multipotency and quiescence in Caenorhabditis elegans dauer larvae

: Tenen, Claudia
: 2019
: Theses
: BiologyMultipotent stem cellsCaenorhabditis elegansMolecular biology

39. Interstitial Telomere Sequences Disrupt Break Induced Replication

: Stivison, Elizabeth Anne
: 2019
: Theses
: GeneticsMolecular biologyTelomereDNA damageDNA replication

40. Investigations of 12α-Hydroxylated Bile Acid Signaling in Intestinal Organoids

: Ahmad, Tiara Rinjani
: 2019
: Theses
: PathologyPhysiologyMolecular biologyBile acids--MetabolismIntestines--Metabolism

41. Liver X Receptor cis-Repression and Cholesterol Efflux Restrain Innate Immunity and Coronary Artery Disease

: Thomas, David George
: 2019
: Theses
: CytologyMolecular biologyBiochemistryAtherosclerosis--PreventionImmunityNuclear receptors (Biochemistry)

42. Mechanism and resistance for antimycobacterial activity of a fluoroquinophenoxazine compound

: Garcia, Pamela K.; Annamalai, Thirunavukkarasu; Wang, Wenjie; Bell, Raven S.; Le, Duc; Martin Pancorbo, Paula; Sikandar, Sabah; Seddek, Ahmed; Yu, Xufen; Sun. Dianqing; Uhlemann, Anne-Catrin; Tiwari, Purushottam B.; Leng, Fenfei; Tse-Dinh, Yuk-Ching
: 2019
: Articles
: MycobacteriumDNA topoisomerase IMolecular biology

43. Mechanisms and therapeutic targeting of NT5C2 mutations in relapsed acute lymphoblastic leukemia

: Dieck, Chelsea
: 2019
: Theses
: BiochemistryLymphoblastic leukemiaDrug resistanceOncologyMutation (Biology)Molecular biology

44. Molecular Approaches to Targeting Oncogenic KRAS and Ferroptosis

: Feng, Huizhong
: 2019
: Theses
: Molecular biologyBiochemistryCytologyBiochemical markersCancerCell death

45. NanoMod: a computational tool to detect DNA modifications using Nanopore long-read sequencing data

: Liu, Qian; Georgieva, Daniela C.; Egli, Dietrich Meinrad; Wang, Kai
: 2019
: Articles
: NanoporesDNA--Computer simulationStatisticsMolecular biology

46. Structural Analyses of the Transient Receptor Potential Channels TRPV3 and TRPV6

: McGoldrick, Luke Lawrence Reedy
: 2019
: Theses
: BiochemistryMolecular biologyTRP channelsStructure-activity relationships (Biochemistry)Ion channels

47. Structural studies of the yeast transcription termination complex Nrd1-Nab3-Sen1

: Zhang, Yinglu
: 2019
: Theses
: BiologyMolecular biologyBiochemistryRNA polymerasesGenetic transcription

48. Studies on RNA Regulation: From Enhancer RNAs to RBBP6 Isoform3

: Chen, Yaqiong
: 2019
: Theses
: Molecular biologyRNAGenetic regulationBiology

49. The Mechanism of NusG-Mediated Transcription-Translation Coupling and The Role of RacR in Transcription Regulation in Escherichia coli

: Bailey, Elizabeth Jean
: 2019
: Theses
: BiochemistryMolecular biologyChemistryGenetic transcription--RegulationEscherichia coli

50. Unbiased Expression Profiling Identifies a Novel Notch Signaling Target RND1 as Regulator of Angiogenesis

: Du, Jing
: 2019
: Theses
: Molecular biologyNeovascularizationRho GTPasesCellular signal transduction

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1. Analysis of Conformational Continuum and Free-energy Landscapes from Manifold Embedding of Single-particle Cryo-EM Ensembles of Biomolecules

2. Bacterial Genome Engineering with CRISPR RNA-Guided Transposons

3. Characterization of pathogenic BicD2 mutations in vitro and in vivo.

4. Single-cell Analysis of Alopecia Areata

5. A p53-independent role for MDM2-MDMX in cell cycle progression

6. Discovery of Novel Ferroptosis Regulators Using Genetic and Lipidomic Analyses

7. Epitranscriptomic Alterations in Alzheimer’s Disease: The Role of MicroRNA Methylation in the Regulation of Tau Proteostasis

8. Function and Regulation of ALS/FTD-associated RNA Binding Protein FUS

9. Leveraging the potential of human iPSC-derived cardiomyocytes: From modeling congenital heart disease to treating myocardial infarction

10. Mutagenic Repair Outcomes of DNA Double-Strand Breaks

11. Neurometabolic alterations after traumatic brain injury: Links to mitochondria-associated ER membranes and Alzheimer’s disease

12. Non-apoptotic Caspase-8 Signaling Mediates Retinal Angiogenesis

13. Phenotypic dissection and therapeutic manipulation of cell differentiation programs in the salivary gland epithelium and human Adenoid Cystic Carcinomas

14. Pparg Drives Luminal Differentiation and Luminal Tumor Formation in the Urothelium

15. Spatially determined olfactory receptor choice is regulated by Nfi-dependent heterochromatin silencing and genomic compartmentalization

16. Stress and Rab35 modulate Alzheimer’s disease-related protein trafficking

17. Structure and Function of a Transposon-Encoded CRISPR-Cas System

18. The role of RNA base modification m⁶A in RNA turnover and genome dynamics in B cell programmed DNA recombination

19. Atf5 Links Olfactory Receptor Induced Stress Response to Proper Neuronal Function

20. Evolutionary and Functional Diversity of Regulatory Factors and Sequences that Coordinate Gene Expression

21. Generative Models for Synthetic Biology

22. Leveraging DNA Damage Response Pathways to Enhance the Precision of CRISPR-Mediated Genome Editing

23. Neuronal Topography in a Cortical Circuit for Innate Odor Valence

24. Proximal-distal patterning of the lung: molecular determinants in lung development and evolution

25. RNA mediated mechanisms of motor neuron death and dysfunction in SMA

26. The autophagosomal perspective: Tissue-specificity and cell-specificity of the autophagic response to starvation in vivo

27. The contribution of bone to the physiology of danger

28. The FYN-TRAF3IP2 gene fusion drives oncogenic NF-κB signaling in peripheral T cell lymphoma

29. The Role of N6-methyladenosine RNA Methylation in the Regulation of Hematopoietic Stem Cells

30. The role of SMARCAD1 during replication stress

31. Understanding the Evolution of Recombination Rate Variation and PRDM9

32. Chloride Intracellular Channel (CLIC) proteins function to modulate Rac1 and RhoA downstream of endothelial G-protein coupled receptors signaling

33. Control of cellular plasticity during tissue remodeling in C. elegans

34. Elevated cellular cholesterol in Familial Alzheimer’s presenilin 1 mutation is associated with lipid raft localization of β-amyloid precursor protein

35. Elucidating synergistic dependencies in lung adenocarcinoma by proteome-wide signaling-network analysis

36. Engineering Responsive Yeast Systems Using Fungal G-Protein-Coupled Receptors

37. ER stress and lipid droplet-dependent proteostasis in response to lipid stress in yeast and a novel congenital muscular dystrophy

38. Function and tissue focus of daf-18/PTEN in maintaining blast cell multipotency and quiescence in Caenorhabditis elegans dauer larvae

39. Interstitial Telomere Sequences Disrupt Break Induced Replication

40. Investigations of 12α-Hydroxylated Bile Acid Signaling in Intestinal Organoids

41. Liver X Receptor cis-Repression and Cholesterol Efflux Restrain Innate Immunity and Coronary Artery Disease

42. Mechanism and resistance for antimycobacterial activity of a fluoroquinophenoxazine compound

43. Mechanisms and therapeutic targeting of NT5C2 mutations in relapsed acute lymphoblastic leukemia

44. Molecular Approaches to Targeting Oncogenic KRAS and Ferroptosis

45. NanoMod: a computational tool to detect DNA modifications using Nanopore long-read sequencing data

46. Structural Analyses of the Transient Receptor Potential Channels TRPV3 and TRPV6

47. Structural studies of the yeast transcription termination complex Nrd1-Nab3-Sen1

48. Studies on RNA Regulation: From Enhancer RNAs to RBBP6 Isoform3

49. The Mechanism of NusG-Mediated Transcription-Translation Coupling and The Role of RacR in Transcription Regulation in Escherichia coli

50. Unbiased Expression Profiling Identifies a Novel Notch Signaling Target RND1 as Regulator of Angiogenesis