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1. ARP2/3- and resection-coupled genome reorganization into repair domains facilitates chromosome translocations

Zagelbaum, Jennifer
2022
Theses
BiologyGenomesDNA repairChromosomesPolymerizationChromatinTranslocation (Genetics)

2. Autophagy and Hematopoietic Stem Cell Potential During Aging

Dellorusso, Paul Vincent
2022
Theses
BiologyGeneticsImmunologyAutophagic vacuolesHematopoietic stem cells--Therapeutic useCells--AgingGlucose--Metabolism

3. Development of genetically intact bioengineered spores of Bacillus subtilis

Flores Quijano, Juan Manuel de Jesus
2022
Theses
BiologyBacillus subtilis--GeneticsPlasmids--GeneticsBiotechnologyNatural pesticidesProbiotics

4. Investigation of Novel lincRNAs SIMALR and RP11-184M15.1 Functions in Inflammatory and Resolving Human Macrophage

Cynn, Esther
2022
Theses
BiologyMacrophagesApoptosisCardiovascular system--DiseasesMonocytes

5. Multiplexed high-throughput screening identifies broadly active rescuers of proteotoxicity

Resnick, Samuel Jackson
2022
Theses
BiologyAmyotrophic lateral sclerosisNervous system--DegenerationCOVID-19 (Disease)DementiaProtein folding

6. Scouring genomes and evolutionary trees for the origins of sex-biased germline mutation

Wu, Felix
2022
Theses
BiologyMutagenesisMammals--GeneticsBaboonsSex chromosomesCell divisionSpermatogenesis

7. Single-cell activity and network properties of dorsal raphe serotonin neurons during emotional behaviors

Paquelet, Grace Elizabeth
2022
Theses
NeurosciencesBiologyMammals--Nervous systemSerotoninEmotionsSerotoninergic mechanisms

8. Systems-Level Approaches to Understanding Protein Synthesis

Metz, Jordan Benjamin
2022
Theses
BiologyComputer scienceBioinformaticsNucleotide sequenceRibosomesProteins--Synthesis--RegulationRNA-protein interactionsAnimal models in research

9. The contribution of 14-3-3 proteins to protein aggregate homeostasis

Herod, Sarah Grace
2022
Theses
GeneticsBiologyAmyloidAlzheimer's disease--EtiologyParkinson's diseaseNervous system--DegenerationMeiosisRNA-protein interactions

10. The development and application of high-throughput tools for functional genomics

Sheng, Jiemin
2022
Theses
BiologyGenomicsNucleotide sequenceDNARNAProteins

11. Understanding and Engineering Multicomponent Living Systems: Examples from Synthetic Genomics and Engineered Living Materials

McBee, Andrew Ross MacKay
2022
Theses
BiologySynthetic biologyGenomicsMetazoaAmino acidsValineMycelium

12. A Comparative Analysis of Genome Rearrangement in Ciliates

Feng, Yi
2021
Theses
BiologyBioinformaticsEvolution (Biology)Gene rearrangementCiliata--GeneticsEuplotesGenetic code

13. Adipocyte-specific Tribbles-1 Regulates Plasma Adiponectin and Lipoprotein Metabolism in Mice

Ha, Elizabeth
2021
Theses
BiologyLipoproteinsMiceCoronary heart diseaseBlood lipidsGenes

14. Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements

Murphy, David
2021
Theses
GeneticsEvolution (Biology)BiologyHuman genomeBiodiversity

15. Computational Framework for the Identification of Neural Circuits Underlying Psychiatric Disorders

Chang, Jonathan
2021
Theses
NeurosciencesComputer scienceBiologyAutism spectrum disordersMutation (Biology)Basal ganglia--DiseasesLimbic system--Diseases

16. Disentangling mutation and selection in human genetic variation: promises and pitfalls

Agarwal, Ipsita
2021
Theses
BiologyGeneticsEvolution (Biology)Mutation (Biology)Human genomeExomes

17. Electromechanical Coupling in Cells and Its Effects on Membrane Tension and Conductance

Jones Molina, John Anthony
2021
Theses
BiophysicsCytologyBiologyCell membranes

18. Framework for Mapping Gene Regulation via Single-cell Genetic Screens

Tan, Xiangtian
2021
Theses
BiologyCytologyGenetic transcription--RegulationCancer cellsProteins--Analysis

19. Function and Regulation of ALS/FTD-associated RNA Binding Protein FUS

Tsai, Yueh-Lin
2021
Theses
BiologyCytologyMolecular biologyRNA-protein interactionsAmyotrophic lateral sclerosisDementia

20. Mechanisms Underlying Phenotypic Heterogeneity in Simplex Autism Spectrum Disorders

Chiang, Andrew Hann
2021
Theses
GeneticsBiologyBioinformaticsAutism spectrum disorders--Genetic aspectsPhenotypeMutagenesis

21. “Message in a Bottle”: Extracellular Vesicle microRNAs as Novel Biomarkers of Environmental Exposures and Health Outcomes

Comfort, Nicole
2021
Theses
Environmental healthBiologyEpidemiologyMicroRNAAsthma in childrenAsthma--Environmental aspectsCity childrenNucleotide sequenceSaliva--Analysis

22. Modeling Gene Therapy for Intractable Developmental and Epileptic Encephalopathy

Aimiuwu, Osasumwen Virginia
2021
Theses
BiologyEpilepsy--Genetic aspectsMutagenesisBrain--Diseases--TreatmentMice--GeneticsGene therapy

23. Mutagenic Repair Outcomes of DNA Double-Strand Breaks

Al-Zain, Amr M.
2021
Theses
BiologyMolecular biologyDouble-stranded RNACancer--EtiologyCancer--Genetic aspectsGenomesMutagenesis

24. Neural circuit control of feature tuning in CA1 during spatial learning

Rolotti, Sebastian Victor
2021
Theses
NeurosciencesBiologyNeurology--ResearchMemory--ResearchHippocampus (Brain)Calcium imagingElectrophysiologyOptogenetics

25. Novel Functions for Dynein Adaptor RILP in Neuronal Autophagy

Khobrekar, Noopur V.
2021
Theses
BiologyBiochemistryDyneinAutophagic vacuolesCell organelles

26. Regulation of heterochromatin formation by the JmjC-domain protein Epe1

Bao, Kehan
2021
Theses
BiologyEukaryotic cells--GeneticsHeterochromatinChromatinDNA

27. Role of Mu-Opioid Receptors in the Behavioral Effects of the Antidepressant Tianeptine

Han, Jaena
2021
Theses
BiologyNeurosciencesDepression, Mental--TreatmentAntidepressantsSerotonin uptake inhibitorsMice

28. Roles of Retinoid Signaling in Urothelial Progenitor Cells

Wiessner, Gregory
2021
Theses
Developmental biologyBiologyEpithelium--PhysiologyBladder

29. Stress and Rab35 modulate Alzheimer’s disease-related protein trafficking

Zhuravleva, Viktoriya
2021
Theses
NeurosciencesBiologyMolecular biologyAlzheimer's disease--ResearchStress (Physiology)Glucocorticoids

30. Structural Studies of NediV-IRES-Mediated Translation Initiation

Altomare, Clara Gilda
2021
Theses
BiologyVirusesRNA virusesRibosomesEukaryotic cellsGenetic translation

31. Ultrastructural analysis of dendritic spine necks reveals a continuum of spine morphologies: Models

Ofer, Netanel; Yuste, Rafael
2021
Data (Information)
NeuronsUltrastructure (Biology)BiologyNeurosciences

32. Utilizing cell-specific chromatin accessibility states to understand appendage patterning and diversification in Drosophila Melanogaster

Loker, Ryan Edmund
2021
Theses
Developmental biologyGeneticsBiologyDrosophila melanogaster--Genetics

33. Adipocytes Secrete Lipid-Laden Exosomes and Influence Local Macrophage Behavior

Flaherty, Stephen
2020
Theses
BiologyLipaseMacrophagesFat cellsAdipose tissues--Analysis

34. Characterization of Primary Cilia and Intraflagellar Transport 20 in the Epidermis

Su, Steven
2020
Theses
CytologyBiologyMedicineSkinStem cells--ResearchCilia and ciliary motion

35. Circadian Regulation of Behavior and Physiology in Drosophila melanogaster

O’Connor, Reed M.
2020
Theses
BiologyNeurosciencesCircadian rhythmsDrosophila melanogasterSleep--Physiological aspects

36. Discovery of New Cancer Therapeutic Contexts for Ferroptosis Inducers and other Small-Molecule Drugs

Ye, Ling Feng
2020
Theses
BiologyCell deathDrug developmentCancer--TreatmentMolecules

37. Elucidating the abilities of MDM2, MDMX and p21 to regulate ferroptosis

Venkatesh, Divya
2020
Theses
BiologyGeneticsLipids--PeroxidationCell deathCancer

38. Evaluation of a precision medicine approach for hnRNP U-related developmental epileptic encephalopathy using a mouse model of disease

Dugger, Sarah Anne
2020
Theses
GeneticsNeurosciencesBiologyGenetic transcription--RegulationNervous system--Diseases

39. Feeding and Gastrointestinal Regulation: A Novel Domain of the Cerebellum

Birkenbach, Kathryn Elise
2020
Theses
NeurosciencesMedical sciencesBiologyCerebellumFood habits--Physiological aspectsDigestion

40. Genetic and Environmental Determinants of Alopecia Areata

2020
Theses
BiologyAlopecia areataNutritionMedical genetics--Research

41. Hierarchical Modularity in the Reassembly of Hydra’s Nervous System

Lovas, Jonathan Roek
2020
Theses
NeurosciencesDevelopmental biologyBiologyHydraNeural circuitry

42. Homeostasis of Adipose Tissue Macrophages

Edwin, Ethan
2020
Theses
BiologyAdipose tissuesMacrophagesOntogenyPhenotype

43. Landscape of the p53 transcriptome and clinical implications

Regunath, Kausik
2020
Theses
BiologyGenomesCancer--Genetic aspectsTumors

44. Light and Temperature Cues Elicit Metabolic Reprogramming in the Non-phototrophic Bacterium Pseudomonas aeruginosa

Kahl, Lisa Juliane
2020
Theses
BiologyMicrobiologyMetabolismBiological rhythmsPhotobiologyBacteria--PhysiologyRespiration

45. Polygenic adaptation after a sudden change in environment

Hayward, Laura K.
2020
Theses
MathematicsBiologyEvolution (Biology)Adaptation (Biology)Ecological assessment (Biology)

46. Predicting Autonomous Promoter Activity Based on Genome-wide Modeling of Massively Parallel Reporter Data

FitzPatrick, Vincent Drury
2020
Theses
BiologyStatisticsPromoters (Genetics)Genomics--Statistical methodsGenetic polymorphisms

47. Role of the Synovial Membrane in Osteoarthritis Pathogenesis and Cartilage Repair

Stefani, Robert
2020
Theses
Biomedical engineeringMechanical engineeringBiologyOsteoarthritis--PathogenesisSynovial membranesArticular cartilage

48. Screening Whole-Genome Sequenced Strains to Investigate Genetic Determinants of Gentle Touch Sensitivity in Caenorhabditis elegans

Lawry, Stephanie Terese
2020
Theses
GeneticsBiologyGenomicsGenomesNematodesTouchNeurosciences

49. Sexually Dimorphic Development of the Caenorhabditis elegans Nervous System

Bayer, Emily Ann
2020
Theses
BiologyCaenorhabditis elegansSexual dimorphism (Animals)Genetic sex determinationTranscription factorsNervous system

50. Single-particle cryo-electron microscopy studies of ribosomes with fragmented 28S rRNA

Gutierrez-Vargas, Cristina
2020
Theses
BiologyStructural bioinformaticsRibosomes--StructureRNATrypanosoma cruziFragmentation reactions