1. Abeta42 oligomers trigger synaptic loss through AMPK-dependent activation of mitochondrial fission and mitophagy Lee, Annie 2018 Theses CytologyNeurosciencesAlzheimer's disease--PathogenesisSynapsesMitochondriaOligomersMolecular biology
2. Adipocyte-specific Tribbles-1 Regulates Plasma Adiponectin and Lipoprotein Metabolism in Mice Ha, Elizabeth 2021 Theses BiologyLipoproteinsMiceCoronary heart diseaseBlood lipidsGenes
3. Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice Kim-Muller, Ja Young; Fan, Jason Chen; R. Kim, Young Jung; Lee, Seung-Ah; Ishida, Emi; Blaner, William S.; Accili, Domenico 2016 Articles Pancreatic beta cellsDiabetes--EtiologyAldehyde dehydrogenaseCytology
4. A Multi-omic Precision Oncology Pipeline to Elucidate Mechanistic Determinants of Cancer Jones, Sunny 2021 Theses Biology--ClassificationCancerOncologyTumorsCancer--Genetic aspects
5. Analysis of Oncogenic Signal Transduction with Application to KRAS Signaling Pathways Broyde, Joshua 2018 Theses BioinformaticsBiometryMolecular biologyCancer--Molecular aspectsCellular signal transductionOncology
6. Analysis of Ureteric Bud Morphogenesis by Reassociation of Fetal Kidney Cells Leclerc, Kevin 2015 Theses KidneysMetalloproteinasesExtracellular matrixMorphogenesis--Molecular aspectsGeneticsMolecular biology
7. A Novel Analytical Framework for Regulatory Network Analysis of Single-Cell Transcriptomic Data Vlahos, Lukas 2023 Theses Cells--AnalysisOncologyNucleotide sequenceAdenocarcinomaPancreas--CancerMammals--Cytology
8. A Novel Human Multi-Tissue System For Preclinical Drug Evaluation And Recapitulation Of Metastasis Chramiec, Alan 2022 Theses Biomedical engineeringOncologyCancer--ChemotherapyTumorsTissue engineeringDrugs--Testing
9. A p53-independent role for MDM2-MDMX in cell cycle progression Klein, Alyssa Michelle 2021 Theses CytologyMolecular biologyBiochemistryCancerMutation
10. Apolipoprotein E and Mitochondria-associated Endoplasmic Reticulum Membrane Dysfunction Tambini, Marc D. 2015 Theses Alzheimer's disease--Genetic aspectsEndoplasmic reticulumMembrane disordersApolipoprotein EAlzheimer's disease--PathogenesisPresenilinsAlzheimer's disease--Molecular aspectsCytologyPathology
11. A Precision Medicine Approach to Understanding KIF1A Associated Neurological Disorder Boyle, Lia 2021 Theses GeneticsNeurosciencesMedicineNervous system--Diseases--EtiologyNervous system--Diseases--Genetic aspectsNervous system--Diseases--TreatmentNervous system--DegenerationAxonsDendrites
12. A Retrotransposon Insertion in the 5' Regulatory Domain of Ptf1a Results in Ectopic Gene Expression and Multiple Congenital Defects in Danforth’s Short Tail Mouse Lugani, Francesca; Arora, Ripla; Papeta, Natalia F.; Patel, Ami M.; Zheng, Zongyu; Sterken, Roel; Singer, Ruth Arielah; Caridi, Gianluca; Mendelsohn, Cathy Lee; Sussel, Lori; Papaioannou, Virginia E.; Gharavi, Ali G. 2013 Articles GeneticsDevelopmental biologyMedicine
13. ARP2/3- and resection-coupled genome reorganization into repair domains facilitates chromosome translocations Zagelbaum, Jennifer 2022 Theses BiologyGenomesDNA repairChromosomesPolymerizationChromatinTranslocation (Genetics)
14. Asymmetric Cell Division in the Generation of Immunity and Tolerance Yen, Bonnie 2018 Theses ImmunologyCell divisionImmunological toleranceMolecular biology
15. A Targetable GATA2-IGF2 Axis Confers Aggressiveness in Chemotherapy Resistant Prostate Cancer Vidal, Samuel J. 2015 Theses Molecular biologyOncology
16. Autophagy and Hematopoietic Stem Cell Potential During Aging Dellorusso, Paul Vincent 2022 Theses BiologyGeneticsImmunologyAutophagic vacuolesHematopoietic stem cells--Therapeutic useCells--AgingGlucose--Metabolism
17. Behavior and Immunity in Drosophila melanogaster Allen, Victoria Wing 2016 Theses Circadian rhythmsAnimal behaviorDrosophila melanogaster--PhysiologyImmunityGeneticsBiology
18. BioArray Software Environment (BASE): a platform for comprehensive management and analysis of microarray data Saal, Lao H.; Troein, Carl; Vallon-Christersson, Johan; Gruvberger, Sofia; Borg, Åke; Peterson, Carsten 2002 Articles BioinformaticsDNA microarraysCytologyGenetics
19. Biological Inference from Single Cell RNA-Sequencing Levitin, Hanna M. 2020 Theses Biology--ClassificationBioinformatics--MethodologyRNAComputational biologyT cells--Research
20. Bone Marrow: A New Way of Modeling a Classic Organ Churchill, Michael John 2016 Theses Cell culture--TechniqueHematopoietic stem cellsAntibody-dependent cell cytotoxicityBone marrowBiologyImmunology
21. BRCA1 and 53BP1 Mediate Reprogramming Through DNA Repair Pathway Choice Georgieva, Daniela Chavdarova 2019 Theses BiologyCytologyDNA repairBRCA genes
22. Calcium imaging of the entire muscle system of Hydra reveals extensive cellular multifunctionality Szymanski, John Robert 2018 Theses BiologyNeurosciencesHydraMusclesCell physiology
23. Carabin Is a Negative Regulator of Cd8+ T-cell-mediated Anti-tumor Immunity Cohen, Adrienne 2022 Theses OncologyImmunologyT cells--Therapeutic useT cells--ResearchCarcinogenesisTumor markersSquamous cell carcinomaBreast--CancerMelanoma--Immunological aspectsCancer--Immunological aspects
24. Characterization of Fluorescent Proteins for Three- and Four-Color Live-Cell Imaging in S. cerevisiae Higuchi-Sanabria, Ryo; Garcia, Enrique Jose; Tomoiaga, Delia; Munteanu, Emilia Laura; Feinstein, Paul; Pon, Liza A. 2016 Articles Green fluorescent proteinImaging systems in medicineCell hybridizationSaccharomyces cerevisiaeCytologyMolecular biology
25. Characterization of pathogenic BicD2 mutations in vitro and in vivo. Yi, Julie Young Joo 2022 Theses CytologyMolecular biologyNeurosciencesMicrotubulesEukaryotic cellsDyneinMutagenesisKinesin
26. Characterization of Primary Cilia and Intraflagellar Transport 20 in the Epidermis Su, Steven 2020 Theses CytologyBiologyMedicineSkinStem cells--ResearchCilia and ciliary motion
27. Characterizing human regulatory genetic variation using CRISPR/Cas9 genome editing Brandt, Margot 2020 Theses GeneticsHuman genetics--VariationCRISPR (Genetics)Medical geneticsGene editing
28. Characterizing the Mechanism of Tumor Suppression by PBRM1 in Clear Cell Renal Cell Carcinoma Schoenfeld, David Aaron 2015 Theses Renal cell carcinomaCancer--Genetic aspectsCarcinogenesisOncogenesAntioncogenesMolecular biologyOncology
29. Chloride Intracellular Channels 1 and 4 function in distinct branches of S1P signaling to regulate endothelial cell behavior and vascular development Jilishitz, Irina 2016 Theses MorphogenesisGrowth factorsNeovascularizationEndothelial cellsMolecular biologyBiochemistry
30. Circadian Regulation of Behavior and Physiology in Drosophila melanogaster O’Connor, Reed M. 2020 Theses BiologyNeurosciencesCircadian rhythmsDrosophila melanogasterSleep--Physiological aspects
31. Computational Tools for Profiling Neural Cells via Molecular Image Data Chen, Shuonan 2023 Theses Biology--ClassificationNeurosciencesNeuronsBiostatisticsMolecular biology
32. Cytoskeletal Regulation of Centromere Maintenance and Function in the Mammalian Cell Cycle Liu, Chenshu 2016 Theses MitosisCytoskeletonCentromereBiologyCytology
33. Deciphering gene dysregulation in disease through population and functional genomics Dhindsa, Ryan Singh 2020 Theses Gene expressionChromatinChromatographic analysisTranscription factorsRNA-protein interactionsNervous system--DiseasesEpilepsyGenetic regulation
34. Delayed neurogenesis leads to altered specification of ventrotemporal retinal ganglion cells in albino mice Bhansali, Punita; Rayport, Ilana Kalin; Rebsam, Alexandra; Mason, Carol Ann 2014 Articles Retinal ganglion cellsAlbinos and albinismNeurosciences
35. Delineating the function, efficacy, and mechanism of a novel preclinical agent for the treatment of pancreatic ductal adenocarcinoma Eberle-Singh, Jaime 2018 Theses OncologyAdenocarcinomaPancreas--CancerCancer--TreatmentMedical sciencesMolecular biology
36. Design and Application of Cationic Nanocarriers to Inhibit Chemotherapy-Induced Breast Cancer Metastasis and Inflammation Akinade, Tolulope 2022 Theses Biomedical engineeringCytologyMedicineCancer--Chemotherapy--ResearchBreast--Cancer--TreatmentBreast--Cancer--ChemotherapyDoxorubicin--Therapeutic usePaclitaxel--Therapeutic useNanoparticlesMice as laboratory animalsCytokinesMetastasis
37. Developing Statistical Methods for Incorporating Complexity in Association Studies Palmer, Cameron Douglas 2017 Theses BioinformaticsHuman genome--ResearchStatisticsGenomics--Statistical methodsResearch--Data processing
38. Developmental plasticity and circuit mechanisms of dopamine-modulated aggression Mahadevia, Darshini 2018 Theses NeurosciencesPsychobiologyDopamineDopaminergic mechanismsAggressivenessAntipsychotic drugs
39. Discovering Master Regulators of Single-Cell Transcriptional States in the Tumor Immune Microenvironment to Reveal Immuno-Therapeutic Targets and Synergistic Treatments Obradovic, Aleksandar 2022 Theses OncologyImmunologyCancer--ImmunotherapyRenal cell carcinomaT cells--Therapeutic useSquamous cell carcinomaBile ducts--CancerProstate--Cancer--Treatment
40. Discovery of New Cancer Therapeutic Contexts for Ferroptosis Inducers and other Small-Molecule Drugs Ye, Ling Feng 2020 Theses BiologyCell deathDrug developmentCancer--TreatmentMolecules
41. Dissecting the mechanisms of antiplasmodial resistance in Plasmodium falciparum Murithi, James Muriungi 2021 Theses ParasitologyAntimalarialsPlasmodium falciparumMalariaGenomes
42. Dissecting the molecular basis of PfCRT-mediated antimalarial drug resistance Gabryszewski, Stanislaw J. 2016 Theses Drug resistanceChloroquineMedical sciencesPlasmodium falciparumMicrobiologyMolecular biologyParasitology
43. Dissecting the non-canonical functions of p53 through novel target identification and p53 acetylation Wang, Shang-Jui 2014 Theses CytologyMolecular biologyAcetylationp53 antioncogeneMice--Genetics
44. Distinct Nuclear-Cytoskeletal LINCages Position the Nucleus for Homeostasis, Polarization and Migration Zhu, Ruijun 2017 Theses CytologyBiologyCell nucleiMolecular biology
45. Distinct Roles for Dynein Regulatory Proteins NudE and NudEL in Brain Development Kemal, Shahrnaz 2013 Theses NeurosciencesDyneinMitosisCell migrationBrain--GrowthKinesinAxons
46. Dysfunctional Sodium Channels and Arrhythmogenesis: Insights into the Molecular Regulation of Cardiac Sodium Channels Using Transgenic Mice Abrams, Jeffrey 2017 Theses BiophysicsSodium channelsTransgenic miceElectrophysiology
47. Electronic Health Record-Derived Phenotyping Models to Improve Genomic Research in Stroke Thangaraj, Phyllis Mary 2020 Theses BioinformaticsGeneticsCerebrovascular diseaseCerebrovascular disease--Risk factorsMedical records--Data processingMachine learning--Industrial applications
48. Endothelial Caspase-9 Activity Exacerbates Edema and Neuronal Dysfunction after Retinal Vein Occlusion Avrutsky, Maria 2017 Theses CytologyEdemaRetina--Blood-vesselsMolecular biology
49. Engineered Bacteria for Cancer Immunotherapy Chowdhury, Sreyan 2021 Theses ImmunologyOncologyCancer--ImmunotherapyBacteriologyT cells--Therapeutic useEscherichia coli--ResearchColey, William
50. Engineering yeasts for in situ production of fungal tetracyclines Baldera Aguayo, Pedro Alexis 2020 Theses ChemistryYeastTetracyclineIrritable colon
51. ER stress and lipid droplet-dependent proteostasis in response to lipid stress in yeast and a novel congenital muscular dystrophy Garcia, Enrique Jose 2019 Theses Molecular biologyCytologyLecithinMuscular dystrophyLipids
52. Establishment and Maintenance of Adult Stem Cell Identity: Specification of the Adult Copper Cell Region of the Drosophila Intestine Driver, Ian 2014 Theses Developmental biologyBiologyAdult stem cellsDrosophila
53. Evaluation of Chloride Intracellular Channels 4 and 1 Functions in Developmental and Pathological Angiogenesis Tung, Jennifer Jean 2012 Theses Developmental biologyCytologyNeovascularizationApoptosisChloride channels
54. Evolutionary and Functional Diversity of Regulatory Factors and Sequences that Coordinate Gene Expression Park, Jimin 2020 Theses Biology--ClassificationMolecular biologyMicrobiologyGenetic regulationGene expressionDNA--Synthesis
55. Evolutionary rate determinants and functional optimization of proteins Usmanova, Dinara R. 2023 Theses Evolution (Biology)Molecular biologyGeneticsProteins
56. Exploring the Plasmodium falciparum Transcriptome Using Hypergeometric Analysis of Time Series (HATS) Scanfeld, Daniel 2013 Theses BioinformaticsParasitologyPlasmodium falciparumMalariaDrug resistance
57. Extrinsic Regulation of Hematopoietic Stem Cells in Health and Disease Decker, Matthew 2018 Theses CytologyBiologyHematopoietic stem cellsBiological control systems
58. Ferroptosis: A Novel Form of Cancer Cell Death Induced by the Small Molecule Erastin Lemberg, Kathryn 2011 Theses BiologyBiochemistryChemistryApoptosisCell deathCancer
59. Functional Characterization of Hippocampal Synapses in a Mouse Mutant of the Dystrobrevin Binding Protein 1 (DTNBP 1) Gene Orozco, Ian Jay 2011 Theses NeurosciencesMice--GeneticsHippocampus (Brain)SynapsesSchizophreniaManic-depressive illnessProtein binding
60. Function and tissue focus of daf-18/PTEN in maintaining blast cell multipotency and quiescence in Caenorhabditis elegans dauer larvae Tenen, Claudia 2019 Theses BiologyMultipotent stem cellsCaenorhabditis elegansMolecular biology
61. Gating mechanisms underlying deactivation slowing by atrial fibrillation mutations and small molecule activators of KCNQ1 Peng, Gary 2017 Theses Atrial fibrillationPotassium channelsMembrane proteinsArrhythmia--PathophysiologyIon channelsBiophysics
62. Generative Models for Synthetic Biology Blazejewski, Tomasz 2020 Theses BioinformaticsBiology--ClassificationMolecular biologySynthetic biologyMachine learningAmino acid sequence
63. Gene Regulatory Compatibility in Bacteria: Consequences for Synthetic Biology and Evolution Johns, Nathan Isaac 2019 Theses MicrobiologyGeneticsGenetic regulationGenetic engineeringSynthetic biology
64. Genetic regulatory variant effects across tissues and individuals Flynn, Elise Duboscq 2021 Theses BioinformaticsMedical geneticsGene expression--ResearchHuman genomeCoronary heart disease--Genetic aspectsCoronary arteriesPhenotype
65. Genetics of ABCA4-associated Diseases and Retinitis Pigmentosa Xie, Yajing 2016 Theses Retinitis pigmentosaRetinitis pigmentosa--Genetic aspectsMedical geneticsRetinal degenerationGeneticsBioinformatics
66. Genome Sequence of the Human Abscess Isolate Streptococcus intermedius BA1 Planet, Paul Joseph; Rampersaud, Ryan; Hymes, Saul R.; Whittier, Susan; Della-Latta, Phyllis; Narechania, Apurva; Daugherty, Sean C.; Santana-Cruz, Ivette; DeSalle, Robert; Ravel, Jacques; Ratner, Adam Jonathan 2013 Articles GeneticsMicrobiologyPathology
67. Genomic and machine-learning analysis of germline variants in cancer Madubata, Chioma 2018 Theses BioinformaticsCytologyGeneticsMachine learningGerm cellsCancer
68. Genomic Evolution of Glioblastoma Ladewig, Erik 2018 Theses GenomicsTumorsComputational biologyBiology
69. Hair Growth Is Induced by Blockade of Macrophage-derived Oncostatin M and Downstream Jak-stat5 Signaling in Hair Follicle Stem Cells Wang, Etienne Cho Ee 2018 Theses CytologyImmunologyBiomedical engineeringJAK-STAT pathwayHair--Growth
70. Host factors regulating retroviral replication by interactions with viral RNA and DNA Wang, Gary Zhe 2016 Theses Retrovirus infectionsRetroviruses--GeneticsHost-virus relationshipsGene expressionRetrovirusesMicrobiologyVirology
71. Identifcation and Characterization of Inerolysin, the Cholesterol Dependent Cytolysin Produced by Lactobacillus Iners Rampersaud, Ryan 2014 Theses MicrobiologyLactobacillusVagina
72. Identification and characterization of tissue-resident memory T cells in humans Kumar, Brahma Vencel 2018 Theses ImmunologyT cellsMedical sciencesMolecular biology
73. Identifying and Targeting Master Regulators of Drug Resistance in Lung Adenocarcinoma through Network Analysis of Tumor Transcriptomic Data Griffin, Aaron Timothy 2023 Theses BioinformaticsBiology--ClassificationStatisticsBiochemical markersLungs--CancerAdenocarcinomaDrug resistance in cancer cellsMachine learning--Industrial applicationsAmerican Society of Clinical OncologyMemorial Sloan-Kettering Cancer Center
74. Identifying Critical Regulatory Elements of Alternative Splicing Recinos, Yocelyn 2023 Theses BiologyMolecular biologyGenetic engineeringRNA splicingExons (Genetics)Mammals--Genetics
75. Immediate axonal retrograde signaling in amyloid-dependent neurodegeneration Walker, Chandler 2017 Theses CytologyNeurosciencesAxonsNervous system--Degeneration
76. Improvements in Molecular Mechanics Sampling and Energy Models Bylund, Joseph 2014 Theses ChemistryDrugs--DesignDrugs--TestingProtein binding
77. Inflammatory Pathways and Prevention Therapies in Placental Infection by Fusobacterium nucleatum So, Jeewon 2019 Theses MicrobiologyNutritionImmunologyOmega-3 fatty acidsPregnant women--Health and hygienePlacenta--Diseases
78. Integration of Functional Genomic Data in Genetic Analysis Chen, Siying 2021 Theses BioinformaticsMedical genetics--ResearchHuman genomeEpigeneticsAutism spectrum disorders--Genetic aspects
79. Investigating the determinants of resistance to quinine and chloroquine using a novel Plasmodium falciparum genetic cross Kanai, Mariko 2023 Theses MicrobiologyGeneticsMolecular biologyPlasmodium falciparumQuinine--Therapeutic useMalaria--TreatmentDrug resistance
80. Investigating the role of the RNA binding protein TDP-43 in Amyotrophic Lateral Sclerosis using animal and cell-based models of disease Lehrer, Helaina 2015 Theses Molecular biologyNeurosciencesBiochemistry
81. Investigating the utility of exome sequencing for kidney disease Groopman, Emily 2019 Theses GeneticsBioinformaticsMedicineKidneys--DiseasesExomes
82. Investigations into pathophysiologic mechanisms and treatment of primary mitochondrial diseases Siegmund, Stephanie 2018 Theses Molecular biologyMitochondrial pathologyRapamycinBiology
83. Leveraging the potential of human iPSC-derived cardiomyocytes: From modeling congenital heart disease to treating myocardial infarction Liu, Bohao 2021 Theses Biomedical engineeringMolecular biologyMedicineMyocardial infarctionCongenital heart diseaseHeart cellsStem cellsHuman beings
84. Lipids on Fire: Identifying and Targeting Subcellular Membranes that Drive Ferroptosis Von Krusenstiern, Alfred Nikolai 2022 Theses BiochemistryCell deathLipids--PeroxidationCancer--TreatmentEndoplasmic reticulumFatty acidsRaman effectConfocal fluorescence microscopy
85. Liver X Receptor cis-Repression and Cholesterol Efflux Restrain Innate Immunity and Coronary Artery Disease Thomas, David George 2019 Theses CytologyMolecular biologyBiochemistryAtherosclerosis--PreventionImmunityNuclear receptors (Biochemistry)
86. Long noncoding RNAs are critical regulators of pancreatic islet development and function Singer, Ruth Arielah 2019 Theses GeneticsEndocrinologyNon-coding RNAIslands of Langerhans
87. Lung localized protective responses to heterosubtypic influenza challenge Paik, Daniel Hyunwook 2020 Theses ImmunologyLungs--InfectionsT cells--Therapeutic useInfluenza A virus
88. Macroautophagy Modulates Synaptic Function in the Striatum Torres, Ciara 2014 Theses RapamycinProteinsCorpus striatumCytologyMolecular biologyPsychology
89. Malarial infections in the context of invasive non-typhoidal Salmonella Lewis, Rebecca Eve 2015 Theses ParasitologyImmunologyMicrobiology
90. Mapping Drug-Microbe Interactions and Evolution in the Human Gut Microbiome Ricaurte, Deirdre 2023 Theses Gastrointestinal system--MicrobiologyMolecular biologyBacteriologyDrugs--MicrobiologyAntibiotics--Side effectsCancer--EtiologyLiver--Cancer
91. Mechanisms and therapeutic targeting of NT5C2 mutations in relapsed acute lymphoblastic leukemia Dieck, Chelsea 2019 Theses BiochemistryLymphoblastic leukemiaDrug resistanceOncologyMutation (Biology)Molecular biology
92. Mechanisms Underlying Mitochondrial Quality Control and Cytokinesis in Budding Yeast Alessi, Dana 2014 Theses CytokinesisSaccharomyces cerevisiaeMitochondriaBiologyCytologyMolecular biology
93. Membrane partitioning by Flotillin-1 facilitates amphetamine-induced dopamine transporter activity Fong, Wendy Mei 2017 Theses BiochemistryNeurosciencesCytologyCell membranesCarrier proteins
94. Mind the developmental gap: Identifying adverse drug effects across childhood to evaluate biological mechanisms from growth and development Giangreco, Nicholas Paul 2022 Theses BioinformaticsDevelopmental biologyChild developmentDrugs--Safety measuresDrugs--ToxicologyMedical statistics
95. Mitochondrial Inheritance and Function in the Lifespan Control of Budding Yeast McFaline Figueroa, Jose Ricardo 2012 Theses CytologyBiologyMicrobiologyMitochondriaYeast--GrowthCell division
96. Modeling the Transcriptional Landscape of in vitro Neuronal Differentiation and ALS Disease Kandror, Elena 2019 Theses BiologyNucleotide sequenceCell differentiationAmyotrophic lateral sclerosis
97. Molecular control of dendritic cell development and function Lau, Colleen 2015 Theses Antigen presenting cellsLymphoid tissuePhagocytesLeukemia--EtiologyCell differentiation--Molecular aspectsDendritic cellsImmunology
98. Multiple myeloma presenting with high-output heart failure and improving with anti-angiogenesis therapy: two case reports and a review of the literature Robin, Jason; Fintel, Bara; Pikovskaya, Olga; Davidson, Charles; Cilley, Jeffrey; Flaherty, James 2008 Articles Medicine
99. Multiplexed high-throughput screening identifies broadly active rescuers of proteotoxicity Resnick, Samuel Jackson 2022 Theses BiologyAmyotrophic lateral sclerosisNervous system--DegenerationCOVID-19 (Disease)DementiaProtein folding
100. NanoMod: a computational tool to detect DNA modifications using Nanopore long-read sequencing data Liu, Qian; Georgieva, Daniela C.; Egli, Dietrich Meinrad; Wang, Kai 2019 Articles NanoporesDNA--Computer simulationStatisticsMolecular biology