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1. A Novel Human Multi-Tissue System For Preclinical Drug Evaluation And Recapitulation Of Metastasis

Chramiec, Alan
2022
Theses
Biomedical engineeringOncologyCancer--ChemotherapyTumorsTissue engineeringDrugs--Testing

2. ARP2/3- and resection-coupled genome reorganization into repair domains facilitates chromosome translocations

Zagelbaum, Jennifer
2022
Theses
BiologyGenomesDNA repairChromosomesPolymerizationChromatinTranslocation (Genetics)

3. Autophagy and Hematopoietic Stem Cell Potential During Aging

Dellorusso, Paul Vincent
2022
Theses
BiologyGeneticsImmunologyAutophagic vacuolesHematopoietic stem cells--Therapeutic useCells--AgingGlucose--Metabolism

4. Carabin Is a Negative Regulator of Cd8+ T-cell-mediated Anti-tumor Immunity

Cohen, Adrienne
2022
Theses
OncologyImmunologyT cells--Therapeutic useT cells--ResearchCarcinogenesisTumor markersSquamous cell carcinomaBreast--CancerMelanoma--Immunological aspectsCancer--Immunological aspects

5. Characterization of pathogenic BicD2 mutations in vitro and in vivo.

Yi, Julie Young Joo
2022
Theses
CytologyMolecular biologyNeurosciencesMicrotubulesEukaryotic cellsDyneinMutagenesisKinesin

6. Design and Application of Cationic Nanocarriers to Inhibit Chemotherapy-Induced Breast Cancer Metastasis and Inflammation

Akinade, Tolulope
2022
Theses
Biomedical engineeringCytologyMedicineCancer--Chemotherapy--ResearchBreast--Cancer--TreatmentBreast--Cancer--ChemotherapyDoxorubicin--Therapeutic usePaclitaxel--Therapeutic useNanoparticlesMice as laboratory animalsCytokinesMetastasis

7. Discovering Master Regulators of Single-Cell Transcriptional States in the Tumor Immune Microenvironment to Reveal Immuno-Therapeutic Targets and Synergistic Treatments

Obradovic, Aleksandar
2022
Theses
OncologyImmunologyCancer--ImmunotherapyRenal cell carcinomaT cells--Therapeutic useSquamous cell carcinomaBile ducts--CancerProstate--Cancer--Treatment

8. Lipids on Fire: Identifying and Targeting Subcellular Membranes that Drive Ferroptosis

Von Krusenstiern, Alfred Nikolai
2022
Theses
BiochemistryCell deathLipids--PeroxidationCancer--TreatmentEndoplasmic reticulumFatty acidsRaman effectConfocal fluorescence microscopy

9. Mind the developmental gap: Identifying adverse drug effects across childhood to evaluate biological mechanisms from growth and development

Giangreco, Nicholas Paul
2022
Theses
BioinformaticsDevelopmental biologyChild developmentDrugs--Safety measuresDrugs--ToxicologyMedical statistics

10. Multiplexed high-throughput screening identifies broadly active rescuers of proteotoxicity

Resnick, Samuel Jackson
2022
Theses
BiologyAmyotrophic lateral sclerosisNervous system--DegenerationCOVID-19 (Disease)DementiaProtein folding

11. Scouring genomes and evolutionary trees for the origins of sex-biased germline mutation

Wu, Felix
2022
Theses
BiologyMutagenesisMammals--GeneticsBaboonsSex chromosomesCell divisionSpermatogenesis

12. Single-cell Analysis of Alopecia Areata

Lee, Yoo Jin
2022
Theses
ImmunologyMolecular biologyAlopecia areata--Animal modelsMiceBaldnessPathologyCytokinesLymphocytesNucleotide sequenceCancer--Treatment

13. Systems-Level Approaches to Understanding Protein Synthesis

Metz, Jordan Benjamin
2022
Theses
BiologyComputer scienceBioinformaticsNucleotide sequenceRibosomesProteins--Synthesis--RegulationRNA-protein interactionsAnimal models in research

14. The development and application of high-throughput tools for functional genomics

Sheng, Jiemin
2022
Theses
BiologyGenomicsNucleotide sequenceDNARNAProteins

15. Tissue-wide dynamics of human anti-viral immunity

Poon, Maya
2022
Theses
ImmunologyT cells--Therapeutic useInfluenza--Immunological aspectsCytomegalovirus infectionsCOVID-19 (Disease)--Treatment

16. Adipocyte-specific Tribbles-1 Regulates Plasma Adiponectin and Lipoprotein Metabolism in Mice

Ha, Elizabeth
2021
Theses
BiologyLipoproteinsMiceCoronary heart diseaseBlood lipidsGenes

17. A Multi-omic Precision Oncology Pipeline to Elucidate Mechanistic Determinants of Cancer

Jones, Sunny
2021
Theses
Biology--ClassificationCancerOncologyTumorsCancer--Genetic aspects

18. A p53-independent role for MDM2-MDMX in cell cycle progression

Klein, Alyssa Michelle
2021
Theses
CytologyMolecular biologyBiochemistryCancerMutation

19. A Precision Medicine Approach to Understanding KIF1A Associated Neurological Disorder

Boyle, Lia
2021
Theses
GeneticsNeurosciencesMedicineNervous system--Diseases--EtiologyNervous system--Diseases--Genetic aspectsNervous system--Diseases--TreatmentNervous system--DegenerationAxonsDendrites

20. Dissecting the mechanisms of antiplasmodial resistance in Plasmodium falciparum

Murithi, James Muriungi
2021
Theses
ParasitologyAntimalarialsPlasmodium falciparumMalariaGenomes