Academic Unit: Biological Sciences | Search Results

1. A Computational Approach to Rational Engineering of Protein Crystallization

: Banayan, Nooriel Elan
: 2023
: Theses
: BiophysicsX-ray crystallographyCrystalloids (Botany)CrystallizationArginineLysine

2. A transcriptomic taxonomy of human microglia: Uncovering roles and regulators in aging and neurologic disease.

: Tuddenham, John Francis
: 2023
: Theses
: NeurosciencesMicrogliaNervous system--Diseases--TreatmentCamptothecinAmyotrophic lateral sclerosisNucleotide sequence

3. Cellular arrangement in Pseudomonas aeruginosa biofilms

: Dayton, Hannah Teckla
: 2023
: Theses
: BiologyPseudomonas aeruginosaBiofilmsDrug resistance in microorganisms

4. Comparative analysis of nuclear proteomes and strain-specific chromosomes in Oxytricha trifallax

: Lu, Michael
: 2023
: Theses
: BiologyCiliata--GeneticsGenomesProteomicsChromosomes

5. Discovery and Optimization of Novel Small-Molecule Inhibitors of Glutathione Peroxidase 4

: Lin, Annie
: 2023
: Theses
: BiologyDrug resistance in cancer cellsCell deathGlutathioneCancer cells--Effect of drugs on

6. Exploring a non-canonical mode of gene regulation mediated by mRNA transcript isoform switching in the context of mammalian development

: Keskin, Abdurrahman
: 2023
: Theses
: BiologyEmbryonic stem cellsGene expressionMammals--GeneticsMammals--Development

7. Functional specification of the Caenorhabditis elegans nervous system by homeodomain transcription factors

: Cros, Cyril Christophe
: 2023
: Theses
: Developmental biologyNeurosciencesCaenorhabditis elegansNervous systemNeurons

8. Genetic Variant Effects on Transcription Factor Regulation

: Li, Xiaoting
: 2023
: Theses
: BiologyHuman genetics--VariationDiseases--Risk factorsHuman genomeGenomicsGenetic transcriptionGene expression

9. Homology-Directed Repair of One- and Two-Ended DNA Double-Strand Breaks

: Kimble, Michael Taylor
: 2023
: Theses
: GeneticsDouble-stranded RNADNA repairGenomesDNA damageYeast--GeneticsGenetic recombination

10. Non-canonical WDR33 Isoforms: Characterization, Regulation, and Functional Significances in STING-Mediated Innate Immune Responses

: Liu, Lizhi
: 2023
: Theses
: Molecular biologyImmunologyBiochemistryAmino acid sequenceGene expressionMessenger RNAOligomerizationInterferon

11. Population genetic models of mutation rate evolution and adaptation and the impact of essential workers in the context of social distancing for epidemic control

: Milligan, William Robert
: 2023
: Theses
: BiologyEvolution (Biology)MutagenesisGerm cellsSocial distancing (Public health)Epidemics--PreventionEpidemiologyAllelomorphismIndustrial hygiene

12. Regulation of EGFR signal transduction and cell division in quiescent Vulval Precursor Cells during dauer developmental arrest

: O'Keeffe, Catherine
: 2023
: Theses
: BiologyDevelopmental biologyCaenorhabditis elegansStem cellsVulvaCell division

13. Regulation of redox metabolism in Pseudomonas aeruginosa biofilms

: Smiley, Marina K.
: 2023
: Theses
: MicrobiologyBiologyPseudomonas aeruginosaBiofilmsBacteriaDenitrificationPhenazineAnti-infective agents

14. Spatially resolved molecular dysfunction in the prefrontal cortex of patients with amyotrophic lateral sclerosis (ALS)

: Petrescu, Joana
: 2023
: Theses
: NeurosciencesAmyotrophic lateral sclerosisNervous system--DiseasesFrontotemporal dementiaPrefrontal cortex

15. SPIDR: The development and application of a highly multiplexed CLIP-seq method

: Wolin, Erica
: 2023
: Theses
: Molecular biologyRNA-protein interactionsRNA--Analysis

16. Structural and Functional Studies of CNG channels

: Hu, Zhengshan
: 2023
: Theses
: BiologyBiochemistryBiophysicsCyclic nucleotides--AnalysisIon channelsCryoelectronicsElectron microscopy

17. Studies on Eukaryotic Pre-mRNA 3'-End Processing: Insights into PAS Recognition and the U7 snRNP activity

: Gutierrez Tamayo, Pedro A.
: 2023
: Theses
: BiologyBiochemical geneticsBiophysicsEukaryotic cells--GeneticsMessenger RNAVertebratesMammals--Molecular genetics

18. The Role of Kinesins in Cell Fate Determination During Neurogenesis

: Helmer, Paige
: 2023
: Theses
: BiologyKinesinNeurogeneticsNeuronsBrain--PhysiologyMammals--Nervous systemNeuroglia

19. The Role of the Tail of the Striatum in Associative Learning

: Stanley, Adrien Trejo
: 2023
: Theses
: NeurosciencesPaired-association learningMiceBasal gangliaSerotoninNoradrenaline

20. The Role of the Type VI Secretion System in the Adaptation of Pseudomonas aeruginosa to the Lung

: Fields, Blanche L.
: 2023
: Theses
: MicrobiologyImmunologyPseudomonas aeruginosa infectionsCystic fibrosis--PatientsLungs--InfectionsProteins--Secretion

21. Understanding the molecular, cellular, and circuit defects characterizing the early stages of Alzheimer’s disease

: Virga, Daniel Michael
: 2023
: Theses
: NeurosciencesAlzheimer's disease--PathophysiologyAlzheimer's disease--EtiologyCytologyMolecular biologyNervous system--DiseasesHippocampus (Brain)SynapsesDendritesMitochondrial pathology

22. Widespread 3D genome reorganization precedes programmed DNA rearrangement in Oxytricha trifallax

: Villano, Danylo Julian
: 2023
: Theses
: BiologyMolecular biologyGeneticsGenomesCiliataRNAGene rearrangement

23. A genetically-encoded biosensor and a conditional gene expression system for investigating Notch activity in vivo

: Shaffer, Justin Matthew
: 2022
: Theses
: Developmental biologyGeneticsGene expressionCell interactionCaenorhabditis elegans--GeneticsExons (Genetics)

24. Analysis of Conformational Continuum and Free-energy Landscapes from Manifold Embedding of Single-particle Cryo-EM Ensembles of Biomolecules

: Seitz, Evan Elliott
: 2022
: Theses
: Molecular biologyBiomoleculesElectron microscopy—Data processingMachine learningRiemannian manifoldsGibbs' free energyPath analysis (Statistics)RibosomesCOVID-19 (Disease)--Data processing

25. A non-canonical Hippo signaling pathway regulates DeltaNp63 in cancer cells

: Low Calle, Ana Maria
: 2022
: Theses
: Molecular biologySquamous cell carcinomaTranscription factors

26. Auditory Tuning in Vocal Learning Songbirds

: Yeh, Yow-Tyng
: 2022
: Theses
: BiologyNeurosciencesSongbirdsBirds--VocalizationBirdsongsSensorimotor cortex

27. Cardiomyopathy at the Intersection of Stem Cells and Tissue Engineering

: Wang, Bryan Zicheng
: 2022
: Theses
: BiologyMyocardium--DiseasesStem cellsGene editingTissue engineeringHeart--Diseases--Genetic aspects

28. Detection of respiratory gas levels by internal sensory neurons in Drosophila larvae

: Lu, Shan
: 2022
: Theses
: NeurosciencesDrosophila--DevelopmentSensory neuronsHypoxia (Water)Carbon dioxideRespiratory gas monitoringInsects--Larvae

29. Development of genetically intact bioengineered spores of Bacillus subtilis

: Flores Quijano, Juan Manuel de Jesus
: 2022
: Theses
: BiologyBacillus subtilis--GeneticsPlasmids--GeneticsBiotechnologyNatural pesticidesProbiotics

30. Expression and Functional Analyses of the Entire Cadherin Gene Family in C. elegans

: Majeed, Maryam
: 2022
: Theses
: BiologyNeurosciencesCaenorhabditis elegans--GeneticsGene expressionCadherins

31. Identification of essential sites of lipid peroxidation in ferroptosis

: Von Krusenstiern, Alfred Nikolai; Stockwell, Brent R.
: 2022
: Data (Information)
: Lipids--PeroxidationLipids--MetabolismCell deathMedicine

32. Identification of essential sites of lipid peroxidation in ferroptosis (Lipidomics Data)

: Von Krusenstiern, Alfred Nikolai; Stockwell, Brent R.
: 2022
: Data (Information)
: Lipids--PeroxidationLipids--MetabolismCell deathMedicine

33. Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection

: Wong Fok Lung, Tania; Charytonowicz, Daniel; Beaumont, Kristin G.; Shah, Shivang; Sridhar, Shwetha H.; Gorrie, Claire L.; Mu, Andre; Hofstaedter, Casey E.; Varisco, David; McConville, Thomas Howe; Drikic, Marija; Fowler, Brandon; Urso, Andreacarola; Shi, Wei; Fucich, Dario; Annavajhala, Medini; Khan, Ibrahim N.; Oussenko, Irina; Francoeur, Nancy; Smith, Melissa L.; Stockwell, Brent R.; Lewis, Ian A.; Hachani, Abderrahman; Upadhyay Baskota, Swikrity; Uhlemann, Anne-Catrin; Ahn, Danielle; Ernst, Robert K.; Howden, Benjamin P.; Sebra, Robert; Prince, Alice S.
: 2022
: Articles
: ImmunosuppressionKlebsiella pneumoniaeLungs--InfectionsNosocomial infectionsMedicine

34. Machine learning classifies ferroptosis and apoptosis cell death modalities with TfR1 immunostaining

: Jin, Jenny; Schorpp, Kenji; Samaga, Daniel; Unger, Kristian; Hadian, Kamyar; Stockwell, Brent R.
: 2022
: Data (Information)
: Cell deathMachine learningClassification

35. Multidimensional encoding of context in auditory cortex

: Shymkiv, Yuriy
: 2022
: Theses
: NeurosciencesAuditory cortexCalcium imagingSensory stimulation

36. Nucleolar transcription and its connections to nucleolar homeostasis and mitochondrial stress responses

: Feng, Shuang
: 2022
: Theses
: Molecular biologyNucleic acidsHomeostasisMitochondriaCarcinogenesisNervous system--Diseases

37. Production and properties of the Pseudomonas aeruginosa R-body virulence factor

: Wang, Bryan
: 2022
: Theses
: MicrobiologyPseudomonas aeruginosaAntibiotics--Therapeutic useBiofilms

38. Real-time observation of vitamin B12 transport by BtuCD-F at the single-molecule level

: Zhu, Lingwei
: 2022
: Theses
: BiophysicsHydrolysisVitamin B12ATP-binding cassette transporters

39. Studies of Caenorhabditis elegans neuronal cell fate

: Tekieli, Tessa
: 2022
: Theses
: NeurobiologyCaenorhabditis elegansCaenorhabditis elegans--GeneticsNervous systemDopaminergic neuronsHomeobox genes

40. The role of Distal antenna in the regulation of D. melanogaster neural stem cell competence

: Benchorin, Gillie
: 2022
: Theses
: Developmental biologyNeurosciencesCytologyDrosophila melanogasterDrosophila melanogaster--PhysiologyGenomesDNA-binding proteinsNuclear proteinsAntennae (Biology)