1. Discovery of RNA-guided DNA integration by CRISPR-associated transposases Klompe, Sanne Eveline 2023 Theses Molecular biologyDNA-protein interactionsRNA-protein interactionsBacterial genomesImmunologyProkaryotesEscherichia coli
2. The role of ER-mitochondria contact sites in the regulation of glucose metabolism: a tale of two mitochondria and its relevance to amyotrophic lateral sclerosis Tamucci, Kirstin Arianna 2023 Theses BiochemistryMolecular biologyNutritionGlucose--MetabolismMitochondriaMitochondrial membranesEndoplasmic reticulumMotor neuronsAmyotrophic lateral sclerosis
3. Analysis of Conformational Continuum and Free-energy Landscapes from Manifold Embedding of Single-particle Cryo-EM Ensembles of Biomolecules Seitz, Evan Elliott 2022 Theses Molecular biologyBiomoleculesElectron microscopy—Data processingMachine learningRiemannian manifoldsGibbs' free energyPath analysis (Statistics)RibosomesCOVID-19 (Disease)--Data processing
4. A non-canonical Hippo signaling pathway regulates DeltaNp63 in cancer cells Low Calle, Ana Maria 2022 Theses Molecular biologySquamous cell carcinomaTranscription factors
5. Bacterial Genome Engineering with CRISPR RNA-Guided Transposons Vo, Phuc Hong 2022 Theses Molecular biologyMicrobiologyBacterial geneticsBacterial genomesTherapeuticsEscherichia coli--GeneticsTransposonsDNACRISPR (Genetics)
6. Characterization of pathogenic BicD2 mutations in vitro and in vivo. Yi, Julie Young Joo 2022 Theses CytologyMolecular biologyNeurosciencesMicrotubulesEukaryotic cellsDyneinMutagenesisKinesin
7. Developing and applying novel imaging methods for human diseases Bekdash, Ramsey Azeez 2022 Theses Molecular biologyBiologyFluorescence microscopyElectrophysiologyDiagnostic imagingCOVID-19 (Disease)--TreatmentMetabolism
8. Noncoding translation mitigation Kesner, Jordan 2022 Theses Biology--ClassificationMolecular biologyCytologyEukaryotic cells--GeneticsAmino acid sequenceGenomesNucleotide sequenceRNA
9. Nucleolar transcription and its connections to nucleolar homeostasis and mitochondrial stress responses Feng, Shuang 2022 Theses Molecular biologyNucleic acidsHomeostasisMitochondriaCarcinogenesisNervous system--Diseases
10. Regulation of synapse density by Pumilio RNA-binding proteins Randolph, Lisa Kathryn 2022 Theses NeurosciencesCytologyMolecular biologyNeuronsSynapsesRNA-protein interactions
11. Single-cell Analysis of Alopecia Areata Lee, Yoo Jin 2022 Theses ImmunologyMolecular biologyAlopecia areata--Animal modelsMiceBaldnessPathologyCytokinesLymphocytesNucleotide sequenceCancer--Treatment
12. The Role of Chromatin in Olfaction Kodra, Albana Lavinia 2022 Theses ChromatinOlfactory receptor genesCOVID-19 (Disease)--Psychological aspectsGeneticsMolecular biologyBiochemistryEpithelium
13. The role of microRNA-219 in Alzheimer’s Disease-related tau proteostasis and pathology Cho, Joshua 2022 Theses Molecular biologyAlzheimer's disease--PathophysiologyNervous system--DiseasesDrosophila melanogasterMicePhosphorylation
14. The role of PPARgamma acetylation and Adipsin in adipose tissue dysfunction Aaron, Nicole 2022 Theses PharmacologyMolecular biologyMedicineAdipose tissuesHomeostasisAcetylationMacrophages
15. A p53-independent role for MDM2-MDMX in cell cycle progression Klein, Alyssa Michelle 2021 Theses CytologyMolecular biologyBiochemistryCancerMutation
16. Discovery of Novel Ferroptosis Regulators Using Genetic and Lipidomic Analyses Bezjian, Carla Tara 2021 Theses CytologyMolecular biologyBiochemistryCell deathGenetic regulationPhospholipids
17. Epitranscriptomic Alterations in Alzheimer’s Disease: The Role of MicroRNA Methylation in the Regulation of Tau Proteostasis Kim, Yoon Anna 2021 Theses NeurosciencesPathologyMolecular biologyAlzheimer's disease--Genetic aspectsMicroRNAMethyltransferasesNervous system--DegenerationPhosphorylationDrosophila--GeneticsRats--GeneticsMice--Genetics
18. Function and Regulation of ALS/FTD-associated RNA Binding Protein FUS Tsai, Yueh-Lin 2021 Theses BiologyCytologyMolecular biologyRNA-protein interactionsAmyotrophic lateral sclerosisDementia
19. Leveraging the potential of human iPSC-derived cardiomyocytes: From modeling congenital heart disease to treating myocardial infarction Liu, Bohao 2021 Theses Biomedical engineeringMolecular biologyMedicineMyocardial infarctionCongenital heart diseaseHeart cellsStem cellsHuman beings
20. Mutagenic Repair Outcomes of DNA Double-Strand Breaks Al-Zain, Amr M. 2021 Theses BiologyMolecular biologyDouble-stranded RNACancer--EtiologyCancer--Genetic aspectsGenomesMutagenesis
21. Neurometabolic alterations after traumatic brain injury: Links to mitochondria-associated ER membranes and Alzheimer’s disease Agrawal, Rishi Raj 2021 Theses Molecular biologyCytologyNeurosciencesBrain--Wounds and injuriesAlzheimer's disease--EtiologyMitochondrial membranes
22. Non-apoptotic Caspase-8 Signaling Mediates Retinal Angiogenesis Johnson, Kendra Vincia 2021 Theses NeurosciencesCytologyMolecular biologyRetina--DiseasesRetina--Blood-vesselsNeovascularizationRetinal degeneration--Animal models
23. Phenotypic dissection and therapeutic manipulation of cell differentiation programs in the salivary gland epithelium and human Adenoid Cystic Carcinomas Viragova, Sara 2021 Theses CytologyMolecular biologySalivary glandsEpithelium--DiseasesAdenoid cystic carcinomaCancer--Radiotherapy
24. Pparg Drives Luminal Differentiation and Luminal Tumor Formation in the Urothelium Tate, Tiffany 2021 Theses OncologyCytologyMolecular biologyUrinary organsBladder--CancerBasal cell carcinoma
25. Spatially determined olfactory receptor choice is regulated by Nfi-dependent heterochromatin silencing and genomic compartmentalization Bashkirova, Elizaveta Vladimirovna 2021 Theses Molecular biologyHeterochromatinOlfactory receptorsOlfactory receptor genes
26. Stress and Rab35 modulate Alzheimer’s disease-related protein trafficking Zhuravleva, Viktoriya 2021 Theses NeurosciencesBiologyMolecular biologyAlzheimer's disease--ResearchStress (Physiology)Glucocorticoids
27. Structure and Function of a Transposon-Encoded CRISPR-Cas System Halpin-Healy, Tyler Sheehan 2021 Theses BiochemistryBiophysicsMolecular biologyVibrio choleraeRNADNA
28. The role of RNA base modification m⁶A in RNA turnover and genome dynamics in B cell programmed DNA recombination Nair, Lekha 2021 Theses ImmunologyMolecular biologyRNADNAMethyltransferasesMethylationGene rearrangement
29. Atf5 Links Olfactory Receptor Induced Stress Response to Proper Neuronal Function Kahiapo, Jerome Keoki 2020 Theses CytologyBiochemistryMolecular biologyOlfactory receptor genesSmellSensory neuronsMammals
30. Evolutionary and Functional Diversity of Regulatory Factors and Sequences that Coordinate Gene Expression Park, Jimin 2020 Theses Biology--ClassificationMolecular biologyMicrobiologyGenetic regulationGene expressionDNA--Synthesis
31. Generative Models for Synthetic Biology Blazejewski, Tomasz 2020 Theses BioinformaticsBiology--ClassificationMolecular biologySynthetic biologyMachine learningAmino acid sequence
32. Leveraging DNA Damage Response Pathways to Enhance the Precision of CRISPR-Mediated Genome Editing Nambiar, Tarun S. 2020 Theses GeneticsMolecular biologyGene editingGenomesDNA
33. Neuronal Topography in a Cortical Circuit for Innate Odor Valence Costantini, Daniel 2020 Theses NeurosciencesMolecular biologyOlfactory receptorsOdorsMiceNeurons
34. Proximal-distal patterning of the lung: molecular determinants in lung development and evolution van Soldt, Benjamin Jonathan 2020 Theses Developmental biologyGeneticsMolecular biologyLungsPulmonary alveoliMammals--Development
35. RNA mediated mechanisms of motor neuron death and dysfunction in SMA Van Alstyne, Meaghan 2020 Theses CytologyMolecular biologySpinal muscular atrophyMotor neuronsRNA
36. The autophagosomal perspective: Tissue-specificity and cell-specificity of the autophagic response to starvation in vivo Yang, Young Joo 2020 Theses Molecular biologyBioinformaticsVeterinary medicineAutophagic vacuoles
37. The contribution of bone to the physiology of danger Berger, Julian Meyer 2020 Theses EndocrinologyNeurosciencesMolecular biologyBonesDanger perception--ResearchMiceRatsHuman beings
38. The FYN-TRAF3IP2 gene fusion drives oncogenic NF-κB signaling in peripheral T cell lymphoma Kim, Christine Sheila 2020 Theses Molecular biologyGeneticsOncologyHTLV (Viruses)CarcinogenesisGene fusion
39. The Role of N6-methyladenosine RNA Methylation in the Regulation of Hematopoietic Stem Cells Lee, Heather 2020 Theses CytologyMolecular biologyHematopoietic stem cellsDNA--MethylationCell differentiation
40. The role of SMARCAD1 during replication stress Joseph, Sarah 2020 Theses Molecular biologyGeneticsBreast--Cancer--Genetic aspectsOvaries--Cancer--Genetic aspectsHeterozygosity
41. Understanding the Evolution of Recombination Rate Variation and PRDM9 Baker, Zachary 2020 Theses Biology--ClassificationEvolution (Biology)Molecular biologyMeiosisGenetic recombination
42. Chloride Intracellular Channel (CLIC) proteins function to modulate Rac1 and RhoA downstream of endothelial G-protein coupled receptors signaling Mao, De Yu 2019 Theses PharmacologyChloride channelsMolecular biologyCytology
43. Control of cellular plasticity during tissue remodeling in C. elegans Aghayeva, Ulkar 2019 Theses NeurosciencesMolecular biologyCaenorhabditis elegansTissue remodelingNeuroplasticity
44. Engineering Responsive Yeast Systems Using Fungal G-Protein-Coupled Receptors Brisbois, James Ronald 2019 Theses Molecular biologyChemistryCell interactionG proteins--ReceptorsYeast fungi
45. ER stress and lipid droplet-dependent proteostasis in response to lipid stress in yeast and a novel congenital muscular dystrophy Garcia, Enrique Jose 2019 Theses Molecular biologyCytologyLecithinMuscular dystrophyLipids
46. Function and tissue focus of daf-18/PTEN in maintaining blast cell multipotency and quiescence in Caenorhabditis elegans dauer larvae Tenen, Claudia 2019 Theses BiologyMultipotent stem cellsCaenorhabditis elegansMolecular biology
47. Interstitial Telomere Sequences Disrupt Break Induced Replication Stivison, Elizabeth Anne 2019 Theses GeneticsMolecular biologyTelomereDNA damageDNA replication
48. Investigations of 12α-Hydroxylated Bile Acid Signaling in Intestinal Organoids Ahmad, Tiara Rinjani 2019 Theses PathologyPhysiologyMolecular biologyBile acids--MetabolismIntestines--Metabolism
49. Liver X Receptor cis-Repression and Cholesterol Efflux Restrain Innate Immunity and Coronary Artery Disease Thomas, David George 2019 Theses CytologyMolecular biologyBiochemistryAtherosclerosis--PreventionImmunityNuclear receptors (Biochemistry)
50. Mechanisms and therapeutic targeting of NT5C2 mutations in relapsed acute lymphoblastic leukemia Dieck, Chelsea 2019 Theses BiochemistryLymphoblastic leukemiaDrug resistanceOncologyMutation (Biology)Molecular biology
51. Molecular Approaches to Targeting Oncogenic KRAS and Ferroptosis Feng, Huizhong 2019 Theses Molecular biologyBiochemistryCytologyBiochemical markersCancerCell death
52. Structural Analyses of the Transient Receptor Potential Channels TRPV3 and TRPV6 McGoldrick, Luke Lawrence Reedy 2019 Theses BiochemistryMolecular biologyTRP channelsStructure-activity relationships (Biochemistry)Ion channels
53. Structural studies of the yeast transcription termination complex Nrd1-Nab3-Sen1 Zhang, Yinglu 2019 Theses BiologyMolecular biologyBiochemistryRNA polymerasesGenetic transcription
54. Studies on RNA Regulation: From Enhancer RNAs to RBBP6 Isoform3 Chen, Yaqiong 2019 Theses Molecular biologyRNAGenetic regulationBiology
55. The Mechanism of NusG-Mediated Transcription-Translation Coupling and The Role of RacR in Transcription Regulation in Escherichia coli Bailey, Elizabeth Jean 2019 Theses BiochemistryMolecular biologyChemistryGenetic transcription--RegulationEscherichia coli
56. Unbiased Expression Profiling Identifies a Novel Notch Signaling Target RND1 as Regulator of Angiogenesis Du, Jing 2019 Theses Molecular biologyNeovascularizationRho GTPasesCellular signal transduction
57. Abeta42 oligomers trigger synaptic loss through AMPK-dependent activation of mitochondrial fission and mitophagy Lee, Annie 2018 Theses CytologyNeurosciencesAlzheimer's disease--PathogenesisSynapsesMitochondriaOligomersMolecular biology
58. Analysis of Oncogenic Signal Transduction with Application to KRAS Signaling Pathways Broyde, Joshua 2018 Theses BioinformaticsBiometryMolecular biologyCancer--Molecular aspectsCellular signal transductionOncology
59. Asymmetric Cell Division in the Generation of Immunity and Tolerance Yen, Bonnie 2018 Theses ImmunologyCell divisionImmunological toleranceMolecular biology
60. Cell-Specific Responses Redefine Acute Kidney Injury Xu, Katherine 2018 Theses Molecular biologyMedicineMicrobiologyAcute renal failureKidneys--Wounds and injuries
61. Delineating the function, efficacy, and mechanism of a novel preclinical agent for the treatment of pancreatic ductal adenocarcinoma Eberle-Singh, Jaime 2018 Theses OncologyAdenocarcinomaPancreas--CancerCancer--TreatmentMedical sciencesMolecular biology
62. Development of a genetically encoded site-specific fluorescent sensor of human cardiac voltage-gated sodium channel inactivation Shandell, Mia 2018 Theses PharmacologySodium channelsMolecular biologyBiosensors
63. Identification and characterization of tissue-resident memory T cells in humans Kumar, Brahma Vencel 2018 Theses ImmunologyT cellsMedical sciencesMolecular biology
64. Integrating psychosocial stress into children’s molecular epidemiology research: An investigation of flame retardants, telomeres and neuroendocrine development Cowell, Whitney J. 2018 Theses EpidemiologyEnvironmental healthMolecular biologyMolecular epidemiologyPolybrominated diphenyl ethersTelomereChild development
65. Investigations into pathophysiologic mechanisms and treatment of primary mitochondrial diseases Siegmund, Stephanie 2018 Theses Molecular biologyMitochondrial pathologyRapamycinBiology
66. Mechanisms of Focal Adhesions Saxena, Mayur 2018 Theses Biomedical engineeringFocal adhesionsMolecular biologyBiomechanics
67. Phosphorylation dependent structural function of DNA-PKcs in DNA repair and hematopoiesis Crowe, Jennifer Lauryn 2018 Theses Molecular biologyBiologyImmunologyPhosphorylationHematopoiesisDNA repair
68. Regulation of Parkin Protein Levels by L-3,4-dihydroxyphenylalanine Kovalchuke, Lyudmila 2018 Theses Molecular biologyPathologyNeurosciencesParkinson's diseaseDopa
69. Regulatory logic of cellular diversity in the nervous system Closser, Michael Edward 2018 Theses Molecular biologyNeurosciencesBioinformaticsNervous systemGene expressionCellular control mechanisms
70. Shared Molecular Features of Inherited and Sporadic ALS/FTD Conlon, Erin Grace 2018 Theses BiochemistryGeneticsNeurosciencesAmyotrophic lateral sclerosisFrontotemporal dementiaMolecular biology
71. The BARD1 BRCT Domain in Tumor Suppression and Genome Stability Billing, David 2018 Theses Molecular biologyCytologyBiochemistryTumor suppressor proteinsGenomes
72. The Molecular Mechanism of Replication Independent Repair of DNA Interstrand Crosslinks Kato, Niyo 2018 Theses BiologyGeneticsDNA repairCrosslinking (Polymerization)Molecular biology
73. The Mre11-Rad50-Xrs2 Complex in the DNA Damage Response Oh, Julyun 2018 Theses BiologyGeneticsMolecular biologyDNA damageDNA repair
74. A Study of the Mechanism of Motor Neuron Death in Amyotrophic Lateral Sclerosis Politi, Kristin Ann 2017 Theses Molecular biologyBiologyNeurosciencesAmyotrophic lateral sclerosisMotor neurons
75. Distinct Nuclear-Cytoskeletal LINCages Position the Nucleus for Homeostasis, Polarization and Migration Zhu, Ruijun 2017 Theses CytologyBiologyCell nucleiMolecular biology
76. Endothelial Caspase-9 Activity Exacerbates Edema and Neuronal Dysfunction after Retinal Vein Occlusion Avrutsky, Maria 2017 Theses CytologyEdemaRetina--Blood-vesselsMolecular biology
77. Hierarchical dynamics of individual RNA helix base pair formation and disruption Hon, Jason J. 2017 Theses ChemistryRNA--StructureField-effect transistorsMolecular biology
78. Investigating the role of ubiquitin in endosomal sorting and processing of amyloid precursor protein Williamson, Rebecca Lynn 2017 Theses Amyloid beta-protein precursorUbiquitinEndosomesNervous system--DiseasesAmyloid beta-proteinNeurosciencesPathologyMolecular biology
79. Making Memories: Modes and Mechanisms of Gene Silencing by the Polycomb Repressive Complexes in Drosophila Coleman, Rory Tristan 2017 Theses MetazoaPlants--DevelopmentDrosophilaDrosophila--GeneticsDrosophila--DevelopmentGene expressionGeneticsMolecular biology
80. Molecular Design as a Tool to Understand and Manipulate Cell Death Gaschler, Michael McQuaid 2017 Theses ChemistryMoleculesCell deathMolecular biology
81. Molecular Dynamics Simulations of Microtubule-associated protein 1A/1B-light chain 3 (LC3) and its membrane associated form(LC3-II) Mathew, Shyno 2017 Theses Chemical engineeringMolecular biologyBioinformaticsAutophagic vacuoleMolecular dynamics
82. Proprioceptor subtype identity specified by limb-derived signals Norovich, Amy L. 2017 Theses NeurosciencesMolecular biologyProprioceptorsSensory neurons
83. PTEN regulates glutamine flux to pyrimidine synthesis and sensitivity to dihydroorotate dehydrogenase inhibition Mathur, Deepti 2017 Theses Pyrimidines--SynthesisFibroblastsMice--EmbryosTumorsMetabolismGlutamine--MetabolismCytologyBiologyMolecular biologyOncology
84. Rbfox splicing factors promote neuronal maturation and axon initial segment assembly Jacko, Martin 2017 Theses NeurosciencesMolecular biologyNeurons
85. Roles of transcription factor T-bet in memory CD4+ T cell generation, function, homeostasis and tissue targeting Chen, Jun Kui 2017 Theses ImmunologyT cells--DifferentiationTranscription factorsMolecular biology
86. RPGRIP1L and FTO – genes implicated in the effects of FTO intronic sequence variants on food intake – also affect adipogenesis and adipocyte biology. Martin-Carli, Jayne Frances 2017 Theses BiochemistryCytologyMolecular biologyObesity--Genetic aspects
87. Single-molecule observations of hRPA, RAD51, and RAD52 on single-stranded DNA Ma, Chu Jian 2017 Theses BiochemistryBiophysicsDNA replicationGenetic recombinationMolecular biology
88. Unraveling the link between the Mdm2-p53 axis and aging Wu, Danyi 2017 Theses BiologyMolecular biologyAgingp53 protein
89. Using Genomic Transgenes and the CRISPR/Cas9 Gene Editing System to Understand How Hedgehog Signaling Regulates Costal2 and Cubitus Interruptus in Drosophila melanogaster Little, Jamie 2017 Theses BiologyHedgehog proteinsMolecular biologyGenes
90. Watching the Replisome: Single-molecule Studies of Eukaryotic DNA Replication Duzdevich, Daniel 2017 Theses DNA replicationMolecular biologyCytologyEukaryotic cells--GeneticsBiologyBiophysics
91. Chloride Intracellular Channels 1 and 4 function in distinct branches of S1P signaling to regulate endothelial cell behavior and vascular development Jilishitz, Irina 2016 Theses MorphogenesisGrowth factorsNeovascularizationEndothelial cellsMolecular biologyBiochemistry
92. Dissecting the molecular basis of PfCRT-mediated antimalarial drug resistance Gabryszewski, Stanislaw J. 2016 Theses Drug resistanceChloroquineMedical sciencesPlasmodium falciparumMicrobiologyMolecular biologyParasitology
93. Expanding the Toolkit for Metabolic Engineering Ng, Yao Zong 2016 Theses BioengineeringMolecular evolutionMicrobial genetic engineeringChemistryMolecular biology
94. Maintenance of Beta Cell Identity and Function Dominguez Gutierrez, Giselle 2016 Theses DiabetesCell physiologyPancreatic beta cellsMolecular biology
95. Molecular Mechanisms of Synaptic Vesicle Degradation Sheehan, Patricia Jane 2016 Theses Synaptic vesiclesNeurosciencesMolecular biologyNeuronsNeural transmissionCytology
96. Ras, p63 and breast cancer Yoh, Kathryn Elizabeth 2016 Theses Breast--CancerCarcinogenesisBreast--Cancer--EtiologyMesenchymeTumor suppressor proteinsOncologyMolecular biology
97. Role of Lysosomes in Nonshivering Thermogenesis Lin, Yuxi 2016 Theses Body temperatureBody temperature--RegulationObesity--Physiological aspectsLysosomesMolecular biologyBiology
98. The Role of SNORD116 in the Neuromolecular Pathogenesis of the Prader-Willi Syndrome Cole, Lisa 2016 Theses Gene expressionGenetic disordersBrain--AbnormalitiesPrader-Willi syndromeBiologyMolecular biologyEndocrinology
99. Analysis of Ureteric Bud Morphogenesis by Reassociation of Fetal Kidney Cells Leclerc, Kevin 2015 Theses KidneysMetalloproteinasesExtracellular matrixMorphogenesis--Molecular aspectsGeneticsMolecular biology
100. A Targetable GATA2-IGF2 Axis Confers Aggressiveness in Chemotherapy Resistant Prostate Cancer Vidal, Samuel J. 2015 Theses Molecular biologyOncology