1. Discovery and Optimization of Novel Small-Molecule Inhibitors of Glutathione Peroxidase 4 Lin, Annie 2023 Theses BiologyDrug resistance in cancer cellsCell deathGlutathioneCancer cells--Effect of drugs on
2. Exploring a non-canonical mode of gene regulation mediated by mRNA transcript isoform switching in the context of mammalian development Keskin, Abdurrahman 2023 Theses BiologyEmbryonic stem cellsGene expressionMammals--GeneticsMammals--Development
3. Genetic Variant Effects on Transcription Factor Regulation Li, Xiaoting 2023 Theses BiologyHuman genetics--VariationDiseases--Risk factorsHuman genomeGenomicsGenetic transcriptionGene expression
4. Population genetic models of mutation rate evolution and adaptation and the impact of essential workers in the context of social distancing for epidemic control Milligan, William Robert 2023 Theses BiologyEvolution (Biology)MutagenesisGerm cellsSocial distancing (Public health)Epidemics--PreventionEpidemiologyAllelomorphismIndustrial hygiene
5. Regulation of EGFR signal transduction and cell division in quiescent Vulval Precursor Cells during dauer developmental arrest O'Keeffe, Catherine 2023 Theses BiologyDevelopmental biologyCaenorhabditis elegansStem cellsVulvaCell division
6. Regulation of redox metabolism in Pseudomonas aeruginosa biofilms Smiley, Marina K. 2023 Theses MicrobiologyBiologyPseudomonas aeruginosaBiofilmsBacteriaDenitrificationPhenazineAnti-infective agents
7. Structural and Functional Studies of CNG channels Hu, Zhengshan 2023 Theses BiologyBiochemistryBiophysicsCyclic nucleotides--AnalysisIon channelsCryoelectronicsElectron microscopy
8. The Role of Kinesins in Cell Fate Determination During Neurogenesis Helmer, Paige 2023 Theses BiologyKinesinNeurogeneticsNeuronsBrain--PhysiologyMammals--Nervous systemNeuroglia
9. Widespread 3D genome reorganization precedes programmed DNA rearrangement in Oxytricha trifallax Villano, Danylo Julian 2023 Theses BiologyMolecular biologyGeneticsGenomesCiliataRNAGene rearrangement
10. Auditory Tuning in Vocal Learning Songbirds Yeh, Yow-Tyng 2022 Theses BiologyNeurosciencesSongbirdsBirds--VocalizationBirdsongsSensorimotor cortex
11. Cardiomyopathy at the Intersection of Stem Cells and Tissue Engineering Wang, Bryan Zicheng 2022 Theses BiologyMyocardium--DiseasesStem cellsGene editingTissue engineeringHeart--Diseases--Genetic aspects
12. Development of genetically intact bioengineered spores of Bacillus subtilis Flores Quijano, Juan Manuel de Jesus 2022 Theses BiologyBacillus subtilis--GeneticsPlasmids--GeneticsBiotechnologyNatural pesticidesProbiotics
13. Expression and Functional Analyses of the Entire Cadherin Gene Family in C. elegans Majeed, Maryam 2022 Theses BiologyNeurosciencesCaenorhabditis elegans--GeneticsGene expressionCadherins
14. Understanding and Engineering Multicomponent Living Systems: Examples from Synthetic Genomics and Engineered Living Materials McBee, Andrew Ross MacKay 2022 Theses BiologySynthetic biologyGenomicsMetazoaAmino acidsValineMycelium
15. A Comparative Analysis of Genome Rearrangement in Ciliates Feng, Yi 2021 Theses BiologyBioinformaticsEvolution (Biology)Gene rearrangementCiliata--GeneticsEuplotesGenetic code
16. Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements Murphy, David 2021 Theses GeneticsEvolution (Biology)BiologyHuman genomeBiodiversity
17. Disentangling mutation and selection in human genetic variation: promises and pitfalls Agarwal, Ipsita 2021 Theses BiologyGeneticsEvolution (Biology)Mutation (Biology)Human genomeExomes
18. Electromechanical Coupling in Cells and Its Effects on Membrane Tension and Conductance Jones Molina, John Anthony 2021 Theses BiophysicsCytologyBiologyCell membranes
19. Framework for Mapping Gene Regulation via Single-cell Genetic Screens Tan, Xiangtian 2021 Theses BiologyCytologyGenetic transcription--RegulationCancer cellsProteins--Analysis
20. Function and Regulation of ALS/FTD-associated RNA Binding Protein FUS Tsai, Yueh-Lin 2021 Theses BiologyCytologyMolecular biologyRNA-protein interactionsAmyotrophic lateral sclerosisDementia
21. Mutagenic Repair Outcomes of DNA Double-Strand Breaks Al-Zain, Amr M. 2021 Theses BiologyMolecular biologyDouble-stranded RNACancer--EtiologyCancer--Genetic aspectsGenomesMutagenesis
22. Novel Functions for Dynein Adaptor RILP in Neuronal Autophagy Khobrekar, Noopur V. 2021 Theses BiologyBiochemistryDyneinAutophagic vacuolesCell organelles
23. Regulation of heterochromatin formation by the JmjC-domain protein Epe1 Bao, Kehan 2021 Theses BiologyEukaryotic cells--GeneticsHeterochromatinChromatinDNA
24. Role of Mu-Opioid Receptors in the Behavioral Effects of the Antidepressant Tianeptine Han, Jaena 2021 Theses BiologyNeurosciencesDepression, Mental--TreatmentAntidepressantsSerotonin uptake inhibitorsMice
25. Structural Studies of NediV-IRES-Mediated Translation Initiation Altomare, Clara Gilda 2021 Theses BiologyVirusesRNA virusesRibosomesEukaryotic cellsGenetic translation
26. Adipocytes Secrete Lipid-Laden Exosomes and Influence Local Macrophage Behavior Flaherty, Stephen 2020 Theses BiologyLipaseMacrophagesFat cellsAdipose tissues--Analysis
27. Elucidating the abilities of MDM2, MDMX and p21 to regulate ferroptosis Venkatesh, Divya 2020 Theses BiologyGeneticsLipids--PeroxidationCell deathCancer
28. Hierarchical Modularity in the Reassembly of Hydra’s Nervous System Lovas, Jonathan Roek 2020 Theses NeurosciencesDevelopmental biologyBiologyHydraNeural circuitry
29. Landscape of the p53 transcriptome and clinical implications Regunath, Kausik 2020 Theses BiologyGenomesCancer--Genetic aspectsTumors
30. Light and Temperature Cues Elicit Metabolic Reprogramming in the Non-phototrophic Bacterium Pseudomonas aeruginosa Kahl, Lisa Juliane 2020 Theses BiologyMicrobiologyMetabolismBiological rhythmsPhotobiologyBacteria--PhysiologyRespiration
31. Predicting Autonomous Promoter Activity Based on Genome-wide Modeling of Massively Parallel Reporter Data FitzPatrick, Vincent Drury 2020 Theses BiologyStatisticsPromoters (Genetics)Genomics--Statistical methodsGenetic polymorphisms
32. Screening Whole-Genome Sequenced Strains to Investigate Genetic Determinants of Gentle Touch Sensitivity in Caenorhabditis elegans Lawry, Stephanie Terese 2020 Theses GeneticsBiologyGenomicsGenomesNematodesTouchNeurosciences
33. Sexually Dimorphic Development of the Caenorhabditis elegans Nervous System Bayer, Emily Ann 2020 Theses BiologyCaenorhabditis elegansSexual dimorphism (Animals)Genetic sex determinationTranscription factorsNervous system
34. Single-particle cryo-electron microscopy studies of ribosomes with fragmented 28S rRNA Gutierrez-Vargas, Cristina 2020 Theses BiologyStructural bioinformaticsRibosomes--StructureRNATrypanosoma cruziFragmentation reactions
35. The Neural Basis of Sugar and Fat Cravings Tan, Hwei-Ee 2020 Theses NeurosciencesBiologySugarGlucoseFatAppetite
36. Applying medicinal chemistry principles to the Olfactory Code Tahirova, Narmin Tahir 2019 Theses BiologyNeurosciencesChemistryOlfactory receptorsPharmaceutical chemistry
37. Computational and Imaging Methods for Studying Neuronal Populations during Behavior Han, Shuting 2019 Theses BiologyNeurosciencesMachine learningBrain--ImagingNeuropsychiatryAnimal behaviorNeurons
38. Life history effects on neutral polymorphism and divergence rates, in autosomes and sex chromosomes Amster, Guy 2019 Theses BiologySex chromosomesGenetic polymorphismsPopulation geneticsChromosomesBiodiversity
39. Novel functions of C9ORF72, a gene involved in ALS/FTD Fomin, Vitalay 2019 Theses BiologyBiochemistryGeneticsCytologyAmyotrophic lateral sclerosisFrontotemporal dementiaGene expression
40. Population Genetics of Mutation Load and Quantitative Traits in Humans Simons, Yuval Benjamin 2019 Theses GeneticsBiologyHuman population geneticsMutation (Biology)
41. Quantifying spatiotemporal dynamics of human gut microbiota and metabolic limitations of cancer cell growth Ji, Brian 2019 Theses BiologyBiological systemsCancer cells--Growth--RegulationGastrointestinal system--MicrobiologyCell metabolism
42. Quantitative trait variation and adaptation in contemporary humans Mostafavi, Hakhamanesh 2019 Theses BiologyGeneticsHuman evolutionGenomes--Data processingHuman genetics--VariationMortality
43. Structural studies of the yeast transcription termination complex Nrd1-Nab3-Sen1 Zhang, Yinglu 2019 Theses BiologyMolecular biologyBiochemistryRNA polymerasesGenetic transcription
44. Studies on RNA Regulation: From Enhancer RNAs to RBBP6 Isoform3 Chen, Yaqiong 2019 Theses Molecular biologyRNAGenetic regulationBiology
45. Allosteric Coupling, Nucleotide Binding and ATP Hydrolysis by Hsp70 Chaperones on a Structural Basis Wang, Wei 2018 Theses BiologyBiochemistryBiophysicsAllosteric regulationHeat shock proteins
46. Investigating The Role Of Signaling Pathways In Adult Stem Cells Governed By Population Asymmetry Melamed, David Eric 2018 Theses BiologyCellular signal transductionAdult stem cells
47. Markers and Mechanisms of β-cell Dedifferentiation Fan, Jason Chen 2018 Theses MedicineBiologyCytologyPancreatic beta cells
48. Metabolic Strategies to Cope with Overcrowding in a Pseudomonas aeruginosa Biofilm Jo, Jeanyoung 2018 Theses BiologyMicrobiologyPseudomonas aeruginosaBiofilmsMicrobial respiration
49. Multi-level analysis of regulation of EGFR signalling during Drosophila melanogaster leg proximal-distal axis patterning Newcomb, Susan Elizabeth 2018 Theses BiologyGeneticsGrowth factors--ReceptorsEpidermal growth factorDrosophila melanogaster
50. On the Role of Sensory Cancellation and Corollary Discharge in Neural Coding and Behavior Enikolopov, Armen 2018 Theses NeurosciencesBiologySensory stimulationCochlear nucleus
51. Spatially restricted regulation of cell competition by the cytokine Spaetzle Alpar, Elif Lale 2018 Theses BiologyGeneticsCytokinesCells--Growth--Regulation
52. Structural Studies of the Integrator Complex -- pre-UsnRNA 3'-end Processing Machinery Wu, Yixuan 2018 Theses BiologyBiochemistryCatalytic RNA
53. The Molecular Mechanism of Replication Independent Repair of DNA Interstrand Crosslinks Kato, Niyo 2018 Theses BiologyGeneticsDNA repairCrosslinking (Polymerization)Molecular biology
54. The Mre11-Rad50-Xrs2 Complex in the DNA Damage Response Oh, Julyun 2018 Theses BiologyGeneticsMolecular biologyDNA damageDNA repair
55. The Physical State of Water in Dormant Bacteria DeLay, Michael 2018 Theses BiophysicsBacteriaBacterial sporesWaterBiology
56. Understand Biology Using Single Cell RNA-Sequencing Ding, Hongxu 2018 Theses BiologyNucleotide sequenceSystems biology
57. Cryo-electron microscopy and single particle reconstructions of the Leishmania major ribosome and of the encephalomyocarditis virus internal ribosome entry site bound to the 40S subunit Jobe, Amy Beth 2017 Theses Electron microscopyRibosomesLeishmaniaRNACryoelectronicsBiologyBiochemistryBiophysics
58. Regulation of Proviral Expression and Post-Translational Modifications in Embryonic Cells Lee, Andreia H. 2017 Theses BiologyVirologyCytologyGenetic regulation
59. Structural and Functional Studies of TRPML1 and TRPP2 Benvin, Nicole Marie 2017 Theses BiologyBiochemistryBiophysicsTRP channelsProteins--Structure
60. Study of Short Forms of P/Q-Type Voltage-Gated Calcium Channels Feng, Qiao 2017 Theses Central nervous systemNeurotransmittersBrain--DiseasesCalcium channelsBiology
61. The Development of an Inducible Akt as a Potential Gene Therapy for Parkinson’s Disease Park, Soyeon 2017 Theses BiologyNeurosciencesParkinson's diseaseGene therapyProtein kinases
62. The roles of Threonine-4 and Tyrosine-1 of the RNA Polymerase II C-Terminal Domain: New insights into transcription from Saccharomyces cerevisiae Yurko, Nathan Michael 2017 Theses BiologyRNA polymerasesGenetic transcriptionSaccharomyces cerevisiae
63. Unraveling the link between the Mdm2-p53 axis and aging Wu, Danyi 2017 Theses BiologyMolecular biologyAgingp53 protein
64. Using Genomic Transgenes and the CRISPR/Cas9 Gene Editing System to Understand How Hedgehog Signaling Regulates Costal2 and Cubitus Interruptus in Drosophila melanogaster Little, Jamie 2017 Theses BiologyHedgehog proteinsMolecular biologyGenes
65. Watching the Replisome: Single-molecule Studies of Eukaryotic DNA Replication Duzdevich, Daniel 2017 Theses DNA replicationMolecular biologyCytologyEukaryotic cells--GeneticsBiologyBiophysics
66. Connecting Cellular Redox State and Community Behavior in Pseudomonas aeruginosa PA14 Okegbe, Chinweike 2016 Theses MorphologyOxidation-reduction reactionBiofilmsBiology
67. Cryo-electron microscopy studies of dynamical features of ribosomes during the translation process Sun, Ming 2016 Theses BiophysicsProteins--StructureRibosomes--StructureRibosomesCryoelectronicsBiologyBiochemistry
68. Developing New Strategies for Engineering Novel Natural Product Metabolic Pathways Patenode, Caroline Anne 2016 Theses BiocatalysisNatural products--SynthesisBiologyMicrobiologyChemistry
69. Learning cell states from high-dimensional single-cell data Levine, Jacob Harrison 2016 Theses BioinformaticsCells--MeasurementMyeloid leukemiaCells--Computer programsBiologyOncology
70. Physiology of Pseudomonas Aeruginosa Phenazine Production and Transport Sakhtah, Hassan 2016 Theses PhenazineMetabolitesBiofilmsPseudomonas aeruginosaBiology
71. Cryo-EM and time-resolved cryo-EM studies on translation Chen, Bo 2015 Theses RibosomesProteins--SynthesisGenetic translationElectron microscopyBiophysicsBiology
72. Deciphering End Resection in Double-Strand Break repair in Saccharomyces cerevisiae Chen, Huan 2015 Theses Saccharomyces cerevisiaeDNA repairDNA damageBiologyMolecular biologyGenetics
73. Identification and Biophysical Characterization of Small Molecules Modulating Protein Disulfide Isomerase in Neurodegenerative Diseases Kaplan, Anna 2015 Theses Nervous system--DegenerationNeuroprotective agentsProtein disulfide isomeraseBiophysicsBiochemistryBiology
74. Regulatory Logic of Pan-neuronal Gene Expression in Caenorhabditis elegans Stefanakis, Nikolaos 2015 Theses BiologyGenetics
75. Structural Studies of the Fungal pre-mRNA 3'-end Processing Machinery Jurado, Ashley Rae 2015 Theses ProteinsRNA splicingScission (Chemistry)Messenger RNAMolecular biologyBiologyBiochemistry
76. The Regulation of PREX2 by Phosphorylation Barrows, Douglas Walker 2015 Theses PhosphorylationInsulin--Mechanism of actionPhosphoinositidesBiologyBiochemistryPharmacology
77. Elucidating the roles of PARP1 and RBBP6 in the regulation of pre-mRNA 3' end processing Campigli Di Giammartino, Dafne 2014 Theses Biology
78. Gene regulatory factors that control the identities of specific neuron types in Caenorhabditis elegans Zhang, Feifan 2014 Theses GeneticsBiology
79. Heterogeneity and Context-Specificity in Biological Systems Litvin, Oren 2014 Theses BiologyBioinformaticsGenetics—ResearchBacterial diversity--Genetic aspectsGenetics--Mathematical models
80. Mid-channel proteolysis of the L-type voltage gated calcium channel and the potential role of amyloid-β precursor protein Henckels, Kathryn 2014 Theses BiologyNeurosciences
81. Molecular Basis for the Recognition of the Regulatory Stem-loop Structures in Eukaryotic Messenger RNAs Tan, Dazhi 2014 Theses Messenger RNARNA-protein interactionsEukaryotic cellsBiologyBiochemistryMolecular biology
83. Structure Characterization of the 70S-BipA Complex Using Novel Methods of Single-Particle Cryo-Electron Microscopy Ho, Danny Nam 2014 Theses Bacterial proteinsElectron microscopyAntibacterial agentsCryoelectronicsBiologyBiophysics
84. Analyzing Genomic Studies and a Screen for Genes that Suppress Information Loss During DNA Damage Repair Pierce, Steven 2013 Theses BiologyCytologyBioinformatics
85. A Novel Platform to Perform Cancer-Relevant Synthetic Dosage Lethality Screens in Saccharomyces cerevisiae Dittmar, John 2013 Theses BioinformaticsBiologyGenetics
86. Designer Exons Inform a Biophysical Model for Exon Definition Arias, Mauricio A. 2013 Theses Exons (Genetics)Molecular biologyBiophysicsMessenger RNABiology
87. Dissecting genetic determinants of transcription factor activity Lee, Eunjee 2013 Theses BiologyBioinformatics
88. Elucidating the Biological Function of PWWP-Domain Containing Protein Complexes Reddy, Bharat 2013 Theses BiologyGeneticsMolecular biology
89. HDAC6 activity is required for efficient polarization and intracellular transport of organelles in directionally migrating cells Salam, Ambar Asghar 2013 Theses Biology
90. Modulation of touch sensitivity in Caenorhabditis elegans Chen, Xiaoyin 2013 Theses NeurosciencesGeneticsBiology
91. Novel Regulatory Mechanisms of Cytoplasmic Dynein: A Role for the Complex Base Weil, Sarah J. 2013 Theses BiologyBiochemistry
93. Serum Regulation of Inhibitor of DNA Binding/Differentiation 1 Expression by a BMP Pathway and BMP Responsive El Lewis, Thera Cathy 2013 Theses BiologyMolecular biology
94. Spatial, temporal and mechanistic characterization of apoptotic death in the developing subventricular zone Marcolino, Bianca 2013 Theses CytologyCell deathDevelopmental neurobiologyApoptosisNeurosciencesBiology
95. Structural and Biochemical Characterizations of the Symplekin-Ssu72-CTD Complex in Pre-mRNA 3' end Processing Xiang, Kehui 2013 Theses BiochemistryGenetic transcriptionRNA polymerasesBiologyMolecular biology
96. Studies of SV40-transformation and the Loss of Growth Factor Requirements Powers, Robert Scott 2013 Theses Biology
97. Complex Regulation of Pax6 Neuronal Progenitors By Rb Family Members During Corticogenesis Naglieri, Benedetta 2012 Theses BiologyCerebral cortexTumor suppressor proteinsRetinoblastomaCarcinogenesis
98. Determining the Role of Trib3 in Neuronal Apoptosis Zareen, Neela 2012 Theses BiologyNeurosciences
99. Gain-of-Function Effects of Mutant p53 Explored Using a Three-Dimensional Culture Model of Breast Cancer Freed-Pastor, William Allen 2012 Theses Biology
100. Impact of adult hippocampal neurogenesis on behavior Denny, Christine 2012 Theses BiologyNeurosciencesPsychologyDevelopmental neurobiologyHippocampus (Brain)--Growth