1998 Articles
Validity of family history for the diagnosis of dementia among siblings of patients with late-onset Alzheimer's disease
We examined 180 siblings of 127 probands with probable or possible Alzheimer's dementia (AD) in a family study of AD. The overall sensitivity of a simple family history questionnaire was 64% and the specificity was 84%. Sensitivity improved 90–100% with minimal decline in specificity when we considered clinic-based vs. Population survey patients. Higher education among informants and the availability of a spouse or a sibling as informant significantly increased sensitivity. Awareness of such factors may improve the yield of the family history in AD using a simple questionnaire. Genet. Epidemiol. 15:215–223, 1998.
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Also Published In
- Title
- Genetic Epidemiology
- DOI
- https://doi.org/10.1002/(sici)1098-2272(1998)15:3<215::aid-gepi1>3.0.co;2-3
More About This Work
- Academic Units
- Neurology
- Published Here
- February 11, 2022