2022 Articles

Genome-wide Admixture Mapping of eGFR and CKD Identify European and African Ancestry-of-Origin Loci in US Hispanics/Latinos.

Nestor, Jordan; Winkler, Cheryl A.

This editorial highlights persistent disparities in chronic kidney disease (CKD) among Black and Hispanic/Latino populations, driven by both social determinants of health and the underrepresentation of these groups in genomic research. We discuss a study that used admixture mapping in a large Hispanic/Latino cohort to identify novel genetic loci associated with kidney function, demonstrating the value of studying diverse, admixed populations. While some findings were validated in an independent cohort, inconsistencies across populations underscore differences in genetic architecture and the limitations of traditional genome-wide approaches. We emphasize that the lack of diversity in genomic studies limits discovery, reduces the applicability of tools such as polygenic risk scores, and risks exacerbating health disparities. We conclude that expanding genomic research in diverse populations is essential to uncover disease mechanisms, improve risk prediction, and ensure equitable advances in precision medicine for kidney disease.

Keywords: Hispanic; Latino; admixture; admixture mapping; chronic kidney disease; eGFR; Genomic medicine