Articles

Assessment of cognition in advanced AD: The test for severe impairment

Jacobs, D.M.; Albert, S.M.; Sano, M.; del Castillo–Castañeda, C.; Paik, M.C.; Marder, K.; Bell, K.; Brandt, J.; Albert, M.S.; Stern, Yaakov

Article abstract The Test for Severe Impairment (TSI) was compared with the Mini-Mental State Examination (MMSE) and a modified MMSE (mMMSE) in a multisite, longitudinal study of AD. The TSI correlated highly with the MMSE ( r = 0.83) and the mMMSE ( r = 0.82), but was not redundant. There was a wide range of scores on the TSI among those scoring in the severely impaired range on the MMSE and mMMSE. The slope of cognitive change over time detected by the TSI was greater than that revealed by the MMSE or the mMMSE. Performance on the TSI was a significant predictor of survival. The TSI is a valid measure that is sensitive to cognitive change over time in severely demented patients with AD.

Subjects

Files

  • thumnail for Jacobs et al. - 1999 - Assessment of cognition in advanced AD The test f.pdf Jacobs et al. - 1999 - Assessment of cognition in advanced AD The test f.pdf application/pdf 164 KB Download File

Also Published In

More About This Work

Academic Units
Neurology
Published Here
February 11, 2022