2022 Articles

Neural substrates of emotional conflict with anxiety in major depressive disorder: Findings from the Establishing Moderators and biosignatures of Antidepressant Response in Clinical Care (EMBARC) randomized controlled trial

Trombello, Joseph M.; Cooper, Crystal M.; Fatt, Cherise Chin; Grannemann, Bruce D.; Carmody, Thomas J.; Jha, Manish K.; Mayes, Taryn L.; Greer, Tracy L.; Yezhuvath, Uma; Aslan, Sina; Pizzagalli, Diego A.; Weissman, Myrna M.; Webb, Christian A.; Dillon, Daniel G.; McGrath, Patrick J.; Fava, Maurizio; Parsey, Ramin V.; McInnis, Melvin G.

Background: The brain circuitry of depression and anxiety/fear is well-established, involving regions such as the limbic system and prefrontal cortex. We expand prior literature by examining the extent to which four discrete factors of anxiety (immediate state anxiety, physiological/panic, neuroticism/worry, and agitation/restlessness) among depressed outpatients are associated with differential responses during reactivity to and regulation of emotional conflict.