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Synthesis of Infective Poliovirus in BSC-1 Monkey Cells Enucleated with Cytochalasin B

Pollack, Robert; Goldman, Robert

BSC-1 monkey kidney cells were enucleated by two cycles of centrifugation in the presence of cytochalasin B. The resulting populations contained 99.5 percent enucleated cells. After infection, newly synthesized poliovirus was recovered from the enucleated populations. Final virus yield per enucleated cell was about one-fifth the yield per infected untreated cell.

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DOI
https://doi.org/10.1126/science.179.4076.915

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Academic Units
Biological Sciences
Published Here
September 13, 2024