2024 Theses Doctoral

Microbial Derived Modulators of Host Health and Behavior

Mavros, Chrystal Felicia

The human body is home to complex microbial communities that are fundamental to our physiology. Utilizing mouse models, behavior assays, gene expression analyses, and probiotic interventions, this research explores the intricate relationship between the gut microbiome, the central nervous system, and the immune system.

I discuss a strain of Escherichia coli Nissle engineered to produce serotonin, revealing its impact on gut function and immune response. I also evaluate butyrate’s potential to alleviate symptoms of Fragile X Syndrome, highlighting the gut-brain axis. Additionally, I study a strain of Bifidobacterium adolescentis and its role in metabolizing bile acids and modulating host immune cells and stress.

Collectively, these studies address the complex interplay between the gut microbiome and host health and behavior, illuminating the therapeutic potential of microbiome manipulation and setting the stage for novel interventions in neurodevelopmental disorders and immune function regulation.