2025 Theses Doctoral

Behavioral Pharmacology of Classical and Novel Psychedelics: Frameworks for Drug Development

Serrano, Inis Chelsy

The therapeutic potential of serotonergic psychedelics has captivated the scientific community, yet fundamental questions remain: (1) Are psychedelic states themselves necessary for their therapeutic effects? and (2) Does the 5-HT2A receptor—responsible for the sensory disturbances of classical psychedelics—play a crucial role in their therapeutic properties?

Through a reverse translation approach, this research investigates the reported clinical effects of psychoactive and psychedelic substances, specifically Ariadne and 5-MeO-DMT, within preclinical frameworks. By elucidating the mechanisms of action and therapeutic potential of these compounds and their analogs, we gain valuable insights that inform the development of novel experimental therapies for psychiatric and neurological conditions. While this research marks significant progress in uncovering the intricate interplay between receptor activation and therapeutic-like effects, it is only the beginning. By providing key mechanistic insights, this work aims to serve as a foundation for future advancements, ultimately driving innovation in the field and improving lives worldwide.