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Kundalini yoga for post-treatment Lyme disease: A preliminary randomized study

Murray, Lilly; Kuvaldina, Mara

We studied adherence to and potential benefit of an 8-week Kundalini yoga (KY) intervention for patients with post-treatment Lyme disease syndrome (PTLDS). Participants were randomly as-signed to 8 weeks of a KY small-group intervention or a waitlist control (WLC). Adherence was measured as attendance at KY group sessions. Primary outcomes assessed pain, pain interference, fatigue, and global health. Secondary outcomes assessed multisystem symptom burden, mood, sleep, physical and social functioning, cognition, and mindfulness. Linear mixed models assessed changes in outcomes over time as a function of treatment group. Although we aimed to enroll 40 participants, we concluded with 29 participants due to recruitment challenges. KY group retention was excellent, but WLC retention was poor. Regarding adherence, KY participants at-tended 75% of the group therapy sessions on average. Regarding primary outcomes, we found no differences between groups. Regarding secondary outcomes, we found significant improvement in cognitive functioning and multisystem symptom burden in the KY group compared to WLC group. We discuss barriers to enrollment and strategies to enhance recruitment and retention in future trials. Despite feasibility challenges, our preliminary efficacy data suggest KY may reduce cognitive complaints and symptom burden associated with PTLDS.


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May 31, 2022