Articles

Intracellular Cyclic AMP Concentration Responds Specifically to Growth Regulation by Serum

Oey, Jan; Vogel, Arthur; Pollack, Robert

Intracellular concentrations of cyclic AMP increase when cells are deprived of serum. Studies with the mouse fibroblast line 3T3, an SV40-transformed subline of 3T3, and six different revertant lines derived from this clone show that a marked increase in cyclic AMP occurs only when the serum concentration is reduced below the minimum necessary for growth of a given line. Conversely, density-dependent inhibition of growth is not accompanied by an increase in cyclic AMP concentration in any line.

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DOI
https://doi.org/10.1073/pnas.71.3.694

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Academic Units
Biological Sciences
Published Here
September 13, 2024