2024 Articles

Why stating hypotheses in grant writing is usually necessary

Xiao, Yunyu; Weissman, Myrna M.

In this viewpoint, we explore the provocative argument by Hernán and Greenland, presented in JAMA, regarding the traditional necessity of stating hypotheses in grant applications. They propose that this convention may hinder the explorative nature of research, calling for a reevaluation that could impact global research practices and methodologies. Hypotheses provide a structured framework crucial for clarifying research questions and facilitating successful funding. However, Hernán and Greenland merge grant writing with research execution, potentially undervaluing the strategic role of hypotheses. We discuss the perspectives of philosophers Karl Popper and Thomas Kuhn, emphasizing the essential role of hypotheses in fostering scientific progress through critical scrutiny and paradigm shifts. While acknowledging the value in Hernán and Greenland's flexibility for data-driven research, we assert that hypotheses remain fundamental in guiding scientific inquiry, balancing innovation with traditional rigor. Our discussion aims to contribute to the evolution of research methodologies, ensuring they are both innovative and grounded in systematic, hypothesis-driven approaches.