2010 Articles
Association Of A Polyadenylation Polymorphism In The Serotonin Transporter And Panic Disorder
Background: Genetic markers in the serotonin transporter are associated with panic disorder (PD). The associated polymorphisms do not include the serotonin transporter-linked polymorphic region and display no obvious functional attributes. A common polymorphism (rs3813034) occurs in one of the two reported polyadenylation signals for the serotonin transporter and is in linkage disequilibrium with the PD-associated markers. If functional, rs3813034 might be the risk factor that explains the association of the serotonin transporter and PD. Methods: Quantitative polymerase chain reaction on human brain samples (n ϭ 65) and lymphoblast cultures (n ϭ 71) was used to test rs3813034 for effects on expression of the polyadenylation forms of the serotonin transporter. rs3813034 was also tested for association in a sample of PD cases (n ϭ 307) and a control sample (n ϭ 542) that has similar population structure. Results: The balance of the two polyadenylation forms of the serotonin transporter is associated with rs3813034 in brain (p Ͻ .001) and lymphoblasts (p Ͻ .001). The balance of the polyadenylation forms is also associated with gender in brain only (p Ͻ .05). Association testing of rs3813034 in PD identified a significant association (p ϭ .0068) with a relative risk of 1.56 and 1.81 for the heterozygous and homozygous variant genotypes, respectively. Conclusions: rs3813034 is a functional polymorphism in the serotonin transporter that alters the balance of the two polyadenylation forms of the serotonin transporter. rs3813034 is a putative risk factor for PD and other behavioral disorders that involve dysregulation of serotonergic neurotransmission.
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- Gyawali et al. - 2010 - Association of a Polyadenylation Polymorphism in t.pdf application/pdf 209 KB Download File
Also Published In
- Title
- Biological Psychiatry
- DOI
- https://doi.org/10.1016/j.biopsych.2009.10.015
More About This Work
- Academic Units
- Epidemiology
- Psychiatry
- Published Here
- February 1, 2022