2023 Articles

Does treatment‐resistant depression need psychotherapy?

Weissman, Myrna M.

Congratulations are well deserved for this review by 27 psychiatric leaders, representing 14 countries, including 294 references1. This highly researched, well-written paper describes the characteristics of treatment-resistant depression (TRD), including prevalence, risks, clinical features, costs, public health burden, management and treatments. Despite the wealth of information provided, lingering throughout the paper is mention of the instability and inconsistency of the TRD definition. Since the paper is about TRD, the reader is left uneasy about what to assume. In fact, the criticism of the term TRD could be a major conclusion of the review.