2020 Theses Doctoral
Homeostasis of Adipose Tissue Macrophages
Adipose tissue macrophages are a heterogeneous component of adipose tissue with poorly defined ontogeny. I test the hypothesis that macrophage populations in murine adipose have distinct ontogenies that determine their functions. In Aim 1, I identify resident and recruited adipose macrophage populations using three complementary cell-tracking techniques. In Aim 2, I characterize the transcriptomes of resident and recruited adipose macrophages. In Aim 3, I increase the expression of either a macrophage recruitment factor or a macrophage growth factor in adipose. Overall, I conclude that there are distinct populations of resident and recruited macrophages in adipose and that macrophage ontogeny is an important factor that determines phenotype.
This item is currently under embargo. It will be available starting 2022-02-05.
More About This Work
- Academic Units
- Nutritional and Metabolic Biology
- Thesis Advisors
- Ferrante, Anthony W.
- Ph.D., Columbia University
- Published Here
- February 12, 2020