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Lack of BCL10 mutations in germ cell tumors and B cell lymphomas

Fakruddin, Mohamed J.; Chaganti, R.S.K.; Vundavalli, Murty V.

The BCL10 gene has recently been cloned from the chromosomal translocation t(1;14)(p22;q32) in a low-grade mucosa-associated lymphoid tissue (MALT) lymphoma, and was implicated in the pathogenesis of this and several other tumor types (Willis et al. 1999). BCL10 is a cellular homolog of the equine herpesvirus-2 E10 gene, which contains an amino-terminal caspase recruitment domain (CARD) and plays a role in apoptosis. Willis et al. 1999 also showed that BCL10 exhibits hypermutations in MALT lymphomas with t(1;14) as well as frequent mutations in 45% of B and T cell lineage lymphomas without the 1p22 chromosomal rearrangements. In addition, they reported BCL10 mutations in cell lines derived from several solid tumor types including three each of male germ cell tumors (GCTs) and mesotheliomas, suggesting that it may be commonly involved in the pathogenesis of many human malignancies. The 1p22 region is affected by frequent deletions in male GCTs (Mathew et al. 1994) and mesotheliomas (Lee et al. 1996), suggesting that inactivation of a critical gene in this region may play a role in the genesis of these tumors.

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February 25, 2020