Academic Commons


Subacute Sclerosing Panencephalitis Causing Rapidly Progressive Dementia and Myoclonic Jerks in a Sexagenarian Woman

Reyes, Antonio Jose; Ramcharan, Kanterpersad; Perot, Sean; Giddings, Stanley Lawrence; Rampersad, Fidel; Gobin, Reanna

Background: Subacute sclerosing panencephalitis (SSPE) is a disease of childhood and adolescence, but can affect adults. Rapidly progressive cognitive decline, seizures including myoclonic jerks, spasticity, ataxia, visual disturbances, and incontinence are typical manifestations.

Case report: A 62-year-old woman who presented with rapidly progressive dementia and myoclonus was diagnosed with SSPE. There was resolution of the movement disorder with clonazepam and valproic acid treatment and some amelioration of cognitive decline after 3 months of therapy with interferon alfa and isoprinosine.

Discussion: With the recent rise in measles cases worldwide, any increased incidence of SSPE would require vigilance for early interventions.


  • thumnail for 680-Article Text-15937-1-10-20190827.pdf 680-Article Text-15937-1-10-20190827.pdf application/pdf 607 KB Download File

Also Published In

Tremor and Other Hyperkinetic Movements

More About This Work

Academic Units
Center for Parkinson's Disease and Other Movement Disorders
Published Here
December 13, 2019
Academic Commons provides global access to research and scholarship produced at Columbia University, Barnard College, Teachers College, Union Theological Seminary and Jewish Theological Seminary. Academic Commons is managed by the Columbia University Libraries.