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Subacute Sclerosing Panencephalitis Causing Rapidly Progressive Dementia and Myoclonic Jerks in a Sexagenarian Woman

Reyes, Antonio Jose; Ramcharan, Kanterpersad; Perot, Sean; Giddings, Stanley Lawrence; Rampersad, Fidel; Gobin, Reanna

Background: Subacute sclerosing panencephalitis (SSPE) is a disease of childhood and adolescence, but can affect adults. Rapidly progressive cognitive decline, seizures including myoclonic jerks, spasticity, ataxia, visual disturbances, and incontinence are typical manifestations.

Case report: A 62-year-old woman who presented with rapidly progressive dementia and myoclonus was diagnosed with SSPE. There was resolution of the movement disorder with clonazepam and valproic acid treatment and some amelioration of cognitive decline after 3 months of therapy with interferon alfa and isoprinosine.

Discussion: With the recent rise in measles cases worldwide, any increased incidence of SSPE would require vigilance for early interventions.

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Also Published In

Title
Tremor and Other Hyperkinetic Movements
DOI
https://doi.org/10.7916/tohm.v0.680

More About This Work

Academic Units
Center for Parkinson's Disease and Other Movement Disorders
Published Here
December 13, 2019