2019 Articles
Subacute Sclerosing Panencephalitis in Older Adulthood
Subacute sclerosing panencephalitis (SSPE) is a devastating brain disorder that typically affects children and adolescents. SSPE is caused by persistent measles virus infection. The mechanisms that facilitate the measles virus entering the brain, and persisting and proliferating there for very long periods are not precisely known. Once inside the brain, the measles viral genome undergoes a series of mutations, particularly in the M and F protein genes. These mutations are considered responsible for viral persistence and transneuronal spread inside the brain. Measles viral genome isolated from human brain tissues demonstrates clustered mutations in the virus genome, particularly in the M gene. These mutations destroy the structure and functioning of the encoded proteins. Complete infectious virus particle has rarely been demonstrated in the brain tissue.1 In the brain, the mutated measles virus triggers an intense inflammatory reaction that leads neuron destruction.
Files
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Also Published In
- Title
- Tremor and Other Hyperkinetic Movements
- DOI
- https://doi.org/10.7916/tohm.v0.719
More About This Work
- Academic Units
- Center for Parkinson's Disease and Other Movement Disorders
- Published Here
- December 17, 2019
Notes
This editorial was written in response to:
Reyes AJ, Ramcharan K, Perot S, Giddings SL, Rampersad F, Gobin R. Subacute Sclerosing Panencephalitis Causing Rapidly Progressive Dementia and Myoclonic Jerks in a Sexagenarian Woman. Tremor Other Hyperkinet Mov. 2019; 9. doi: 10.7916/tohm.v0.680