History of periodontal treatment and risk for intrauterine growth restriction (IUGR)

Ananth, Cande V.; Andrews, Howard F.; Papapanou, Panos N.; Ward, Angela M.; Bruzelius, Emilie; Conicella, Mary L.; Albert, David A.

To explore the hypothesis that maternal periodontitis is associated with increased risk for Intrauterine Growth Restriction (IUGR), we examined the risk of IUGR in relation to periodontal treatment before, during and after pregnancy.

We conducted a retrospective cohort analysis of insurance claims data from 2009 to 2012 for women who delivered a singleton live birth (n = 32,168). IUGR was examined as a function of type and timing of dental treatment, adjusting for potential confounders in logistic regression. Sensitivity analysis evaluated the potential effects of unmeasured confounding.

Women who received periodontal treatment after delivery, indicating the presence of untreated periodontal disease during pregnancy, had significantly higher odds of IUGR compared to women who received no periodontal treatment (adjusted OR 1.5, 95% CI 1.2, 1.8).

Periodontal treatment provided in the immediate postpartum period, a proxy for periodontitis during gestation, was associated with increased risk of IUGR.


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Also Published In

BMC Oral Health

More About This Work

Academic Units
Obstetrics and Gynecology
Dental Medicine
Published Here
March 8, 2019


Periodontal treatment, Fetal inflammatory response, Intrauterine growth restriction