Academic Commons

Articles

Anti-GAD Antibody-associated Syndrome Presenting with Limb Myoclonus

Manzke, Pedro; Grippe, Talyta; Tavares, Georgia L.; Leal, Lucas C.; Roze, Emmanuel; Apartis, Emmanuelle; Dias, Ronaldo Maciel; Ferreira, André G. F.

Background: The clinical spectrum of anti-glutamic acid decarboxylase (GAD) antibody-associated neurologic syndromes is expanding, with focal, generalized, and atypical forms.

Case Report: We describe a 59-year-old female showing continuous right lower limb myoclonus and mild encephalopathy. These symptoms started 2 weeks prior to evaluation. The patient had great improvement with intravenous steroids. An autoantibody panel was positive for anti-GAD.

Discussion: Various clinical manifestations, including myoclonus, may relate to anti-GAD antibodies. The treatment options available include symptomatic drugs, intravenous immunoglobulin, steroids, and other immunosuppressant agents.

Files

Also Published In

Title
Tremor and Other Hyperkinetic Movements
DOI
https://doi.org/10.7916/D8NK4XVP

More About This Work

Academic Units
Center for Parkinson's Disease and Other Movement Disorders
Published Here
February 19, 2019
Academic Commons provides global access to research and scholarship produced at Columbia University, Barnard College, Teachers College, Union Theological Seminary and Jewish Theological Seminary. Academic Commons is managed by the Columbia University Libraries.