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Complete Resolution of Symptoms of Primary Orthostatic Tremor with Perampanel

Ruiz-Julian, Maria; Orozco, Jorge Luis; Gironell, Alexandre

Background: Primary orthostatic tremor (POT) is an infrequent disorder whose physiopathology is unknown. Current medication is largely ineffective or only offers mild benefits.

Case Report: A 75-year-old female with refractory POT treated with 4 mg/day of perampanel achieved complete symptom resolution. Owing to adverse effects, the patient reduced intake to 2 mg/day, but even at this lower dose the benefit was maintained.

Discussion: We report the complete resolution of POT symptoms using low doses of perampanel, an antiepileptic drug that blocks glutamate-mediated post-synaptic excitation. Further controlled studies are necessary to confirm this finding.

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Title
Tremor and Other Hyperkinetic Movements
DOI
https://doi.org/10.7916/D8QZ3SZD

More About This Work

Academic Units
Center for Parkinson's Disease and Other Movement Disorders
Published Here
February 13, 2019