Refractory macular hole repaired by autologous retinal graft and blood clot

Wu, An-Lun; Chuang, Lan-Hsin; Wang, Nan-Kai; Chen, Kuan-Jen; Liu, Laura; Yeung, Ling; Chen, Tun-Lu; Hwang, Yih-Shiou; Wu, Wei-Chi; Lai, Chi-Chun

Background: To evaluate the surgical technique using autologous retinal graft (ARG) and autologous blood clot (ABC) for the management of refractory macular holes (MHs).

Methods: This study was a retrospective, consecutive, interventional case series. Six eyes of 6 patients who underwent vitrectomy combined with ARG and ABC for the treatment of refractory MH were reviewed. Visual and anatomic outcomes were evaluated.

Results: The mean age was 59.0 ± 9.9 years. All cases had multiple vitreoretinal procedures including vitrectomy and gas fluid exchange before patient presentation. The average numbers of vitrectomies were 2.3 ± 0.5, and those of gas fluid exchange were 3 ± 1.7. Closure of the macular hole was achieved in four (66.7%) cases at last follow-up. The mean follow-up time was 25.2 ± 15.6 months. The averaged BCVA before and after 12 months of the surgery improved from 20/591 to 20/244.

Conclusions: This surgical technique using ARG and ABC provide an option for the treatment of refractory MHs.


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Also Published In

BMC Ophthalmology

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Academic Units
Published Here
February 19, 2019


Refractory macular hole, Retinal graft, Autologous blood clot