Articles

Allele-specific Expression Reveals Interactions Between Genetic Variation And Environment

Knowles, David A; Davis, Joe R; Edgington, Hilary; Raj, Anil; Favé, Marie-Julie; Zhu, Xiaowei; Potash, James B.; Weissman, Myrna M.; Shi, Jianxin; Levinson, Douglas F.; Awadalla, Philip; Mostafavi, Sara; Montgomery, Stephen B; Battle, Alexis

Identifying interactions between genetics and the environment (GxE) remains challenging. We have developed EAGLE, a hierarchical Bayesian model for identifying GxE interactions based on associations between environmental variables and allele-specific expression. Combining whole-blood RNA-seq with extensive environmental annotations collected from 922 human individuals, we identified 35 GxE interactions, compared with only four using standard GxE interaction testing. EAGLE provides new opportunities for researchers to identify GxE interactions using functional genomic data.

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Also Published In

Title
Nature Methods
DOI
https://doi.org/10.1038/nmeth.4298

More About This Work

Academic Units
Epidemiology
Psychiatry
Published Here
February 1, 2022

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Allele-specific Expression Reveals Interactions Between Genetic Variation And Environment