2017 Articles
Allele-specific Expression Reveals Interactions Between Genetic Variation And Environment
Identifying interactions between genetics and the environment (GxE) remains challenging. We have developed EAGLE, a hierarchical Bayesian model for identifying GxE interactions based on associations between environmental variables and allele-specific expression. Combining whole-blood RNA-seq with extensive environmental annotations collected from 922 human individuals, we identified 35 GxE interactions, compared with only four using standard GxE interaction testing. EAGLE provides new opportunities for researchers to identify GxE interactions using functional genomic data.
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Knowles et al. - 2017 - Allele-specific expression reveals interactions be.pdf application/pdf 546 KB Download File
Also Published In
- Title
- Nature Methods
- DOI
- https://doi.org/10.1038/nmeth.4298
More About This Work
- Academic Units
- Epidemiology
- Psychiatry
- Published Here
- February 1, 2022