2001 Articles
Memory performance in healthy elderly without Alzheimer’s disease: effects of time and apolipoprotein-E
Transgenic mice expressing human APOE-4 develop an age-dependent decline in memory without pathological features of Alzheimer’s disease (AD). This implicates APOE in the maintenance of memory during normal senescence, but parallel human studies are limited because longitudinal investigations of memory usually do not exclude patients with AD or “questionable” AD (QD). The current study examined the effect of APOE on cognitive function over time in elderly without dementia. We hypothesized that, compared to other APOE alleles memory decline even in healthy elderly would be greater among those with an APOE-4.
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Also Published In
- Title
- Neurobiology of Aging
- DOI
- https://doi.org/10.1016/s0197-4580(01)00223-8
More About This Work
- Academic Units
- Neurology
- Published Here
- February 11, 2022