2021 Articles
MTOR and Beta Cell Adaptation in T2D
Beta cells are exquisite sensors of the organism’s nutritional status, and a key metabolic regulator via insulin secretion. Systemic insulin requirements vary during the day, but also through life in response to pathophysiological circumstances such as pregnancy or the insulin resistance associated with obesity. These changes impose a burden on beta cells, which must adapt to conditions of higher metabolic load by increasing insulin synthesis and secretion. This adaptation can be achieved by increases in beta cell mass (hyperplasia and hypertrophy), as well as enhanced function per unit of mass.
Files
-
J Clin Endocrinol Metab 2021 Bartolomé.pdf application/pdf 91.3 KB Download File
Also Published In
- Title
- The Journal of Clinical Endocrinology & Metabolism
- DOI
- https://doi.org/10.1210/clinem/dgaa906
More About This Work
- Academic Units
- Medicine
- Published Here
- February 4, 2025