Articles

MTOR and Beta Cell Adaptation in T2D

Bartolomé, Alberto; Pajvani, Utpal B.

Beta cells are exquisite sensors of the organism’s nutritional status, and a key metabolic regulator via insulin secretion. Systemic insulin requirements vary during the day, but also through life in response to pathophysiological circumstances such as pregnancy or the insulin resistance associated with obesity. These changes impose a burden on beta cells, which must adapt to conditions of higher metabolic load by increasing insulin synthesis and secretion. This adaptation can be achieved by increases in beta cell mass (hyperplasia and hypertrophy), as well as enhanced function per unit of mass.

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Also Published In

Title
The Journal of Clinical Endocrinology & Metabolism
DOI
https://doi.org/10.1210/clinem/dgaa906

More About This Work

Academic Units
Medicine
Published Here
February 4, 2025