Academic Commons

Articles

Clinical Trials in Hiv-Associated Cognitive Impairment: Cognitive and Functional Outcomes

Schifitto, Giovanni; Kieburtz, Karl; McDermott, Michael P.; McArthur, Justin C.; Marder, Karen; Sacktor, Ned; Palumbo, Donna; Selnes, Ola A.; Stern, Yaakov; Epstein, Leon G.; Albert, Steven M.

Cognitive and functional outcomes are of primary interest in the design of efficacy trials in HIV-associated cognitive impairment. In a longitudinal cohort study, weak associations were found between measures of cognitive performance and commonly used measures of daily functioning (mostly self-report measures) in HIV-infected individuals. Modifications of current functional scales or new functional instruments are needed to assess the clinical relevance of cognitive changes in clinical trials of HIV-associated cognitive impairment.

Files

  • thumnail for Schifitto-2001-Clinical trials in HIV-associat.pdf Schifitto-2001-Clinical trials in HIV-associat.pdf application/pdf 242 KB Download File

Also Published In

More About This Work

Academic Units
Neurology
Published Here
February 22, 2018