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Characterization of Farmington virus, a novel virus from birds that is distantly related to members of the family Rhabdoviridae

Palacios, Gustavo; Forrester, Naomi; Savji, Nazir; Travassos da Rosa, Amelia P; Guzman, Hilda; DeToy, Kelly; Popov, Vsevolod; Walker, Peter; Lipkin, W. Ian; Vasilakis, Nikos; Tesh, Robert

Background: Farmington virus (FARV) is a rhabdovirus that was isolated from a wild bird during an outbreak of epizootic eastern equine encephalitis on a pheasant farm in Connecticut, USA. Findings: Analysis of the nearly complete genome sequence of the prototype CT AN 114 strain indicates that it encodes the five canonical rhabdovirus structural proteins (N, P, M, G and L) with alternative ORFs (> 180 nt) in the N and G genes. Phenotypic and genetic characterization of FARV has confirmed that it is a novel rhabdovirus and probably represents a new species within the family Rhabdoviridae. Conclusions: In sum, our analysis indicates that FARV represents a new species within the family Rhabdoviridae.

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Also Published In

Title
Virology Journal
DOI
https://doi.org/10.1186/1743-422X-10-219

More About This Work

Academic Units
Center for Infection and Immunity
Published Here
September 9, 2014

Notes

Farmington virus (FARV), Family Rhabdoviridae, Next generation sequencing, Phylogeny