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Theses Doctoral

Improved mono-synaptic tracing tools for mapping, monitoring,

Reardon, Thomas Robert

This work concerns the use of engineered genetic tools to build maps of the mammalian nervous system. Within the practice of circuit neuroscience, one of the most effective tools to emerge in recent years are the neurotropic viruses. Among these are modified strains of rabies virus which are made safe for laboratory use. We introduce here a novel form of engineered rabies virus with substantially improved utility for exploring the structure and function of neural circuits. Additionally, using this new tool, an investigation of an important motor circuit, the cortico-striatal circuit, is presented.

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More About This Work

Academic Units
Neurobiology and Behavior
Thesis Advisors
Jessell, Thomas M.
Degree
Ph.D., Columbia University
Published Here
October 14, 2016
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