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Psychotropic medication use among patients with celiac disease

Zylberberg, Haley M.; Ludvigsson, Jonas F.; Green, Peter H. R.; Lebwohl, Benjamin

Background
Celiac disease is a multi-system disorder with manifestations that may result in psychiatric disorders. We assessed the prevalence of medication use to treat psychiatric disorders in celiac disease patients.


Methods
We conducted a cross-sectional study of patients undergoing esophagogastroduodenoscopy over 9-years at a celiac disease referral center. We compared the prevalence of psychotropic medication use among celiac disease patients (n = 1293) to a control group (n = 1401) with abdominal pain or reflux.


Results
Among all patients the mean age was 48.4 years, most were female (69.5%), and 22.7% used any psychotropic medication. There was no difference between overall psychotropic medication use among celiac disease patients and controls (23.9% vs 21.8%, OR 1.16; 95% CI 0.96–1.39, p = 0.12). However, those with celiac disease were more likely to use antidepressants on univariate (16.4% vs 13.4%, p = 0.03) and multivariate analysis (OR 1.28; 95% CI 1.03–1.59; p = 0.03). Use of psychotropic medications was not associated with disease duration or mode of presentation of celiac disease.


Conclusions
Celiac disease patients use psychotropic medications at similar rates as those with other gastrointestinal diseases, though subgroup analysis suggests they may use more antidepressants. Future studies should investigate whether celiac disease is associated with mood disorders that are not treated with medications.

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More About This Work

Academic Units
Medicine
Celiac Disease Center
Epidemiology
Published Here
April 24, 2018

Notes

Celiac disease, Psychiatric disorders, Epidemiology, Depression, Anxiety

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