Plasma Amyloid Beta-Peptide 1-42 and Incipient Alzheimer's Disease

Mayeux, Richard Paul; Tang, Mingxin; Jacobs, Diane; Manly, Jennifer J.; Bell, Karen L.; Merchant, Carol; Small, Scott A.; Stern, Yaakov; Wisniewski, Henry M.; Mehta, Pankaj D.

Mutations in the amyloid precursor protein and presenilin 1 and 2 genes result in elevated plasma levels of the amyloid beta-peptide species terminating at amino acid residue 42 (A beta1-42). In a longitudinal study of unrelated elderly individuals, those who subsequently developed Alzheimer's disease had higher plasma levels of A beta1-42 at entry than did those who remained free of dementia. The results indicate that elevated plasma levels of the released A beta peptide A beta1-42 may be detected several years before the onset of symptoms, supporting that extracellular A beta1-42 plays an important role in the pathogenesis of late-onset Alzheimer's disease.


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February 23, 2018