1999 Articles
Plasma Amyloid Beta-Peptide 1-42 and Incipient Alzheimer's Disease
Mutations in the amyloid precursor protein and presenilin 1 and 2 genes result in elevated plasma levels of the amyloid beta-peptide species terminating at amino acid residue 42 (A beta1-42). In a longitudinal study of unrelated elderly individuals, those who subsequently developed Alzheimer's disease had higher plasma levels of A beta1-42 at entry than did those who remained free of dementia. The results indicate that elevated plasma levels of the released A beta peptide A beta1-42 may be detected several years before the onset of symptoms, supporting that extracellular A beta1-42 plays an important role in the pathogenesis of late-onset Alzheimer's disease.
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- Mayeux-1999-Plasma amyloid beta-peptide 1-42 a.pdf application/pdf 7.15 MB Download File
Also Published In
- Title
- Annals of Neurology
- DOI
- https://doi.org/10.1002/1531-8249(199909)46:3<412::AID-ANA19>3.0.CO;2-A
More About This Work
- Academic Units
- Neurology
- Published Here
- February 23, 2018