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Predicting genes for orphan metabolic activities using phylogenetic profiles

Chen, Lifeng; Vitkup, Dennis

Homology-based methods fail to assign genes to many metabolic activities present in sequenced organisms. To suggest genes for these orphan activities we developed a novel method that efficiently combines local structure of a metabolic network with phylogenetic profiles. We validated our method using known metabolic genes in Saccharomyces cerevisiae and Escherichia coli. We show that our method should be easily transferable to other organisms, and that it is robust to errors in incomplete metabolic networks.

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Also Published In

Title
Genome Biology
DOI
https://doi.org/10.1186/gb-2006-7-2-r17

More About This Work

Academic Units
Systems Biology
Publisher
BioMed Central
Published Here
September 9, 2014