Academic Commons

Articles

Electrocardiographic left atrial abnormality and silent vascular brain injury: The Northern Manhattan Study

Hunter, Madeleine D.; Park Moon, Yeseon; DeCarli, Charles; Gutierrez Contreras, Jose; Wright, Clinton B.; Di Tullio, Marco R.; Sacco, Ralph L.; Kamel, Hooman; Elkind, Mitchell S.

Hypothesis
We hypothesized that P wave terminal Force in the V1 lead (PTFV1) would be associated with leukoaraiosis and subclinical infarcts, especially cortical infarcts, in a population-based, multi-ethnic cohort.

Methods
PTFV1 was collected manually from baseline electrocardiograms of clinically stroke-free Northern Manhattan Study participants. Investigators read brain MRIs for superficial infarcts, deep infarcts, and white matter hyperintensity volume (WMHV). WMHV was adjusted for head size and log transformed, achieving a normal distribution. Logistic regression models investigated the association of PTFV1 with cortical and with all subclinical infarcts. Linear regression models examined logWMHV. Models were adjusted for demographics and risk factors.

Results
Among 1174 participants with PTFV1 measurements, the mean age at MRI was 70 ± 9 years. Participants were 14.4% white, 17.6% black, and 65.8% Hispanic. Mean PTFV1 was 3587.35 ± 2315.62 μV-ms. Of the 170 subclinical infarcts, 40 were cortical. PTFV1 ≥ 5000 μV-ms was associated with WMHV in a fully adjusted model (mean difference in logWMHV 0.15, 95% confidence interval 0.01–0.28). PTFV1 exhibited a trend toward an association with cortical infarcts (unadjusted OR per SD change logPTFV1 1.30, 95% CI 0.94–1.81), but not with all subclinical infarcts.

Conclusion
Electrocardiographic evidence of left atrial abnormality was associated with leukoaraiosis.

Files

  • thumnail for journal.pone.0203774 (1).pdf journal.pone.0203774 (1).pdf application/pdf 632 KB Download File

Also Published In

More About This Work

Academic Units
Neurology
Medicine
Epidemiology
Published Here
November 19, 2018
Academic Commons provides global access to research and scholarship produced at Columbia University, Barnard College, Teachers College, Union Theological Seminary and Jewish Theological Seminary. Academic Commons is managed by the Columbia University Libraries.