Progressive Ataxia and Palatal Tremor: Think about POLG Mutations
Background: Progressive ataxia and palatal tremor (PAPT) can be observed in both acquired brainstem or cerebellar lesions and genetic disorders.
Phenomenology shown: PAPT due to mutation in POLG, the gene encoding the mitochondrial DNA polymerase.
Educational value: POLG mutation should be considered in patients with PAPT, particularly when additional clues such as a sensory neuronopathy or an ophthalmoplegia are present.
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Also Published In
- Tremor and Other Hyperkinetic Movements
More About This Work
- Academic Units
- Center for Parkinson's Disease and Other Movement Disorders
- The Center for Digital Research and Scholarship
- Published Here
- November 2, 2016