Post-operative cognitive function following general versus regional anesthesia, a systematic review

Davis, Nicholas; Lee, Ka-Eun Melissa; Lin, Albert Yen; Lynch, Lisa Renee; Monteleone, Matthew P.; Falzon, Louise; Ispahany, Nighat A.; Lei, Susan Yi

The effect of anesthetic technique on postoperative outcomes remains in question. This systematic review compares the role of regional versus general anesthesia, with a particular focus on postoperative cognitive function. Potentially relevant articles were identified by searching publicly available computerized databases for this systematic review. Any surgical procedure was accepted with the exception of cardiac, carotid, and neurosurgical procedures. Any regional anesthetic technique was accepted unless combined with a general anesthetic or in conjunction with propofol as a sedative. Any measure of postoperative cognitive function was accepted as long as it was performed no sooner than 7 days postoperatively. Sixteen studies met inclusion criteria and were included in the final analysis. Three studies showed some difference in cognitive function between regional and general anesthesia, whereas the remaining 13 showed no difference between regional and general anesthesia on postoperative cognitive function.


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Also Published In

Journal of Neurosurgical Anesthesiology

More About This Work

Academic Units
Long Health Sciences Library
Center for Behavioral Cardiovascular Health
Lippincott, Williams and Wilkins
Published Here
March 9, 2016