2012 Theses Doctoral
Mitochondrial inheritance and cell cycle regulation in Saccharomyces cerevisiae
Movement and positional control of mitochondria and other organelles are coordinated with cell cycle progression in the budding yeast, Saccharomyces cerevisiae. Recent studies have revealed a checkpoint that inhibits cytokinesis when there are severe defects in mitochondrial inheritance. An established checkpoint signaling pathway, the mitotic exit network (MEN), participates in this process. Here, we describe mitochondrial motility during inheritance in budding yeast, emerging evidence for mitochondrial quality control during inheritance, and organelle inheritance checkpoints for mitochondria and other organelles.
- Crider_columbia_0054D_10482.pdf application/pdf 4.69 MB Download File
More About This Work
- Academic Units
- Pathobiology and Molecular Medicine
- Thesis Advisors
- Pon, Liza A.
- Ph.D., Columbia University
- Published Here
- January 10, 2012