Academic Commons

Articles

The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB

Kandel, Eric

The analysis of the contributions to synaptic plasticity and memory of cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB has recruited the efforts of many laboratories all over the world. These are six key steps in the molecular biological delineation of short-term memory and its conversion to long-term memory for both implicit (procedural) and explicit (declarative) memory. I here first trace the background for the clinical and behavioral studies of implicit memory that made a molecular biology of memory storage possible, and then detail the discovery and early history of these six molecular steps and their roles in explicit memory.

Files

  • thumnail for 302875d3759b4043e1d0ab931de6f239.zip 302875d3759b4043e1d0ab931de6f239.zip binary/octet-stream 256 KB Download File

Also Published In

Title
Molecular Brain
DOI
https://doi.org/10.1186/1756-6606-5-14

More About This Work

Academic Units
Neuroscience
Publisher
BioMed Central
Published Here
September 8, 2014
Academic Commons provides global access to research and scholarship produced at Columbia University, Barnard College, Teachers College, Union Theological Seminary and Jewish Theological Seminary. Academic Commons is managed by the Columbia University Libraries.