Academic Commons

Theses Doctoral

Neuronal Laterality in Caenorhabditis elegans: Morphological and Functional Aspects

Goldsmith, Andrew D.

The ASE neurons of C. elegans are an excellent model to study neuronal asymmetry. Lateralization with respect to their genetic fate and function has been well studied, but their more subtle asymmetries have not. This work describes three such asymmetries: that of amino acid gustation, associative learning, and morphological size. In the first two of these, I found a previously uncharacterized asymmetric neuronal response with respect to amino acid gustation, and expand on the known asymmetry with respect to associative salt learning. Most of this thesis focuses on a discovered size asymmetry in the ASE pair of neurons: characterizing it, providing a functional significance, and describing some of its genetic underpinnings. Size asymmetry and the mechanisms of overall neuron growth are not well-studied, but do have functional consequences in higher organisms. This work hopefully furthers our understandings of these processes and of neuronal development in general.

Files

  • thumnail for Goldsmith_columbia_0054D_10057.pdf Goldsmith_columbia_0054D_10057.pdf application/pdf 48.9 MB Download File

More About This Work

Academic Units
Genetics and Development
Thesis Advisors
Hobert, Oliver
Degree
Ph.D., Columbia University
Published Here
April 13, 2011
Academic Commons provides global access to research and scholarship produced at Columbia University, Barnard College, Teachers College, Union Theological Seminary and Jewish Theological Seminary. Academic Commons is managed by the Columbia University Libraries.