Academic Commons

Articles

Visit-to-visit and 24-h blood pressure variability: association with endothelial and smooth muscle function in African Americans

Diaz, Keith; Veerabhadrappa, P.; Kashem, M. A.; Thakkar, S. R.; Feairheller, D. L.; Sturgeon, K. M.; Ling, C.; Williamson, S. T.; Kretzschmar, J.; Lee, H.; Grimm, H.; Babbit, D. M.; Vin, C.; Fan, X.; Crabbe, D. L.; Brown, M. D.

The purpose of this study was to investigate the association of visit-to-visit and 24-h blood pressure (BP) variability with markers of endothelial injury and vascular function. We recruited 72 African Americans who were non-diabetic, non-smoking and free of cardiovascular (CV) and renal disease. Office BP was measured at three visits and 24-h ambulatory BP monitoring was conducted to measure visit-to-visit and 24-h BP variability, respectively. The 5-min time-course of brachial artery flow-mediated dilation and nitroglycerin-mediated dilation were assessed as measures of endothelial and smooth muscle function. Fasted blood samples were analyzed for circulating endothelial microparticles (EMPs). Significantly lower CD31+CD42− EMPs were found in participants with high visit-to-visit systolic blood pressure (SBP) variability or high 24-h diastolic blood pressure (DBP) variability. Participants with high visit-to-visit DBP variability had significantly lower flow-mediated dilation and higher nitroglycerin-mediated dilation at multiple time-points. When analyzed as continuous variables, 24-h mean arterial pressure variability was inversely associated with CD62+ EMPs; visit-to-visit DBP variability was inversely associated with flow-mediated dilation normalized by smooth muscle function and was positively associated with nitroglycerin-mediated dilation; and 24-h DBP variability was positively associated with nitroglycerin-mediated dilation. All associations were independent of age, gender, body mass index and mean BP. In conclusion, in this cohort of African Americans visit-to-visit and 24-h BP variability were associated with measures of endothelial injury, endothelial function and smooth muscle function. These results suggest that BP variability may influence the pathogenesis of CV disease, in part, through influences on vascular health.

Files

  • thumnail for Diaz_J_Hum_Hypertens_2013_PMC.pdf Diaz_J_Hum_Hypertens_2013_PMC.pdf application/download 349 KB Download File

Also Published In

Title
Journal of Human Hypertension
DOI
https://doi.org/10.1038/jhh.2013.33

More About This Work

Academic Units
Center for Behavioral Cardiovascular Health
Publisher
Nature Publishing Group
Published Here
April 14, 2016
Academic Commons provides global access to research and scholarship produced at Columbia University, Barnard College, Teachers College, Union Theological Seminary and Jewish Theological Seminary. Academic Commons is managed by the Columbia University Libraries.