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Abstracts (Summaries)

MicroRNA expression in HTLV-1 infection and pathogenesis

De Bellis, Gianluca; Corti, Giorgio; Zanovello, Paola; Bronte, Vincenzo; Guffanti, Alessandro; Basso, Katia; Corradin, Alberto; Pise-Masison, Cynthia A.; Bortoluzzi, Stefania; Biasiolo, Marta; Ruggero, Katia; D’Agostino, Donna M.; Ciminale, Vincenzo

Our laboratory is examining the profiles of microRNA expression in ATLL cells and infected T-cell lines using microarrays and small RNA libraries.

Microarray analysis of ATLL samples revealed 6 upregulated and 21 downregulated microRNAs in ATLL cells compared to CD4+ T-cell controls. Potential targets for deregulated microRNAs were identified by integrating microRNA and mRNA expression profiles. Current experiments are aimed at verifying these predicted microRNA-target interactions.

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Academic Units
Pathology and Cell Biology
Publisher
BioMed Central
Published Here
September 9, 2014