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A Reliable Way to Detect Endogenous Murine β-Amyloid

Teich, Andrew Franklin; Patel, Miteshkumar V.; Arancio, Ottavio

Unraveling the normal physiologic role of β-amyloid is likely crucial to understanding the pathogenesis of Alzheimer's disease. However, progress on this question is currently limited by the high background of many ELISAs for murine β-amyloid. Here, we examine the background signal of several murine β-amyloid ELISAs, and conclude that the majority of the background is from non-APP derived proteins. Most importantly, we identify ELISAs that eliminate this background signal.

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Pathology and Cell Biology
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May 8, 2013
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