Academic Commons

Articles

Exploring the Neural Basis of Cognitive Reserve in Aging

Steffener, Jason; Stern, Yaakov

The concept of reserve arose from the mismatch between the extent of brain changes or pathology and the clinical manifestations of these brain changes. The cognitive reserve hypothesis posits that individual differences in the flexibility and adaptability of brain networks underlying cognitive function may allow some people to cope better with brain changes than others. Although there is ample epidemiologic evidence for cognitive reserve, the neural substrate of reserve is still a topic of ongoing research. Here we review some representative studies from our group that exemplify possibilities for the neural substrate of reserve including neural reserve, neural compensation, and generalized cognitive reserve networks. We also present a schematic overview of our ongoing research in this area. This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease.

Files

  • thumnail for Exploring the neural basis of cognitive reserv.pdf Exploring the neural basis of cognitive reserv.pdf application/pdf 457 KB Download File

Also Published In

Title
Biochimica et Biophysica Acta--Molecular Basis of Disease
DOI
https://doi.org/10.1016/j.bbadis.2011.09.012

More About This Work

Academic Units
Neurology
Published Here
February 23, 2018
Academic Commons provides global access to research and scholarship produced at Columbia University, Barnard College, Teachers College, Union Theological Seminary and Jewish Theological Seminary. Academic Commons is managed by the Columbia University Libraries.