2013 Reports

Mirtazapine exposure during pregnancy: literature review and implications

Stillman, Sarah

Depression is one of the most commonly diagnosed mental disorders in America, and it's prevalent in 7-9% of pregnancies, which means its effects impact the mother, fetus and whole family. Pregnancy is a stressful time, physically and mentally. Coupled with maternal depression, it can increase the risk of impaired behavioral, cognitive and birth outcomes for the fetus. Therefore, some form of treatment is necessary. However more severe cases of depression might require an antidepressant. Mirtazapine is a newer antidepressant that has properties particularly helpful for relieving nausea and vomiting, which seem particularly appropriate for women experiencing morning sickness. However the risks and benefits of using mirtazapine and other antidepressants during pregnancy are unclear. Conflicting and even contradictory evidence provides an unclear path for pregnant mothers and clinicians. The current literature review hoped to summarize what has been found on exposure to mirtazap! ine in pregnancy and compare it to findings on other commonly used medications like SSRIs and TCAs.