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Mechanism of tau transfer: insights from cell culture and animal models

Wu, Jessica W.; Dickstein, Dara; Duff, Karen E.

Objective: Tau inclusions composed of tau fibrils are one of the key hallmarks of Alzheimer’s disease and other tauopathies. Studies from transgenic animal models and human AD pathological cases suggest that tau inclusions spread from the transentorhinal cortex to mono and transynaptically connected regions of the hippocampus and neocortical regions. This study examines cell-to-cell propagation of pathological tau in cell culture and in vivo animal models.

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Also Published In

Title
Molecular Neurodegeneration
DOI
https://doi.org/10.1186/1750-1326-8-S1-P50

More About This Work

Academic Units
Taub Institute
Pathology and Cell Biology
Publisher
BioMed Central
Published Here
September 9, 2014