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Results of soy-based meal replacement formula on weight, anthropometry, serum lipids and blood pressure during a 40-week clinical weight loss trial

Fontaine, Kevin; Yang, Dongyan; Gadbury, Gary; Heshka, Stanley; Schwartz, Linda; Murugesan, Radha; Kraker, Jennifer; Heo, Moonseong; Heymsfield, Steven B.; Allison, David

To evaluate the intermediate-term health outcomes associated with a soy-based meal replacement, and to compare the weight loss efficacy of two distinct patterns of caloric restriction. Ninety overweight/obese (28 < BMI ≤ 41 kg/m2) adults received a single session of dietary counseling and were randomized to either 12 weeks at 1200 kcal/day, 16 weeks at 1500 kcal/d and 12 weeks at 1800 kcal/d (i.e., the 12/15/18 diet group), or 28 weeks at 1500 kcal/d and 12 weeks at 1800 kcal/d (i.e., the 15/18 diet group). Weight, body fat, waist circumference, blood pressure and serum lipid concentrations were measured at 4-week intervals throughout the 40-week trial. Subjects in both treatments showed statistically significant improvements in outcomes. A regression model for weight change suggests that subjects with larger baseline weights tended to lose more weight and subjects in the 12/15/18 group tended to experience, on average, an additional 0.9 kg of weight loss compared with subjects in the 15/18 group. Both treatments using the soy-based meal replacement program were associated with significant and comparable weight loss and improvements on selected health variables.

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Also Published In

Title
Nutrition Journal
DOI
https://doi.org/10.1186/1475-2891-2-14

More About This Work

Academic Units
Institute of Human Nutrition
Surgery
Publisher
BioMed Central
Published Here
September 8, 2014