2017 Articles
The Number of Pulses Needed to Measure Corticospinal Excitability by Navigated Transcranial Magnetic Stimulation: Eyes Open vs. Close Condition
Objective: Motor evoked potentials (MEPs) obtained by transcranial magnetic stimulation (TMS) enable measures of the corticospinal excitability (CSE). However the reliability of TMS-derived CSE measures is suboptimal due to appreciable pulse-topulse MEP amplitude variability. We thus calculated how many TMS–derived MEPs will be needed to obtain a reliable CSE measure in awake adult subjects, in the eyes open (EO) and eyes closed (EC) conditions. Methods: Twenty healthy adults (70% male) received 40 consecutive navigated TMS pulses (120% resting motor threshold, RMT) in the EO or EC conditions on two separate days in randomized order. Results: For either the EO or EC condition, the probability that the 95% confidence interval (CI) derived from consecutive MEP amplitude measured included the true CSE, increased when the number of consecutive stimuli increased (EO: p = 0.05; EC: p = 0.001). No significant effect of RMT, Mini-Mental State Examination (MMSE) score, or gender on the CSE estimates was identified. At least 34 consecutive stimuli were required to obtain a most reliable CSE estimate in the EO condition and 31 in the EC condition. Conclusion: Our findings indicate that >30 consecutive MEPs may be necessary in order to obtain a CSE measure in healthy adults.
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Also Published In
- Title
- Frontiers in Human Neuroscience
- DOI
- https://doi.org/10.3389/fnhum.2017.00121
More About This Work
- Academic Units
- Psychiatry
- Published Here
- January 25, 2018